Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gomes, JAP; Azar, DT; Baudouin, C; Efron, N; Hirayama, M; Horwath-Winter, J; Kim, T; Mehta, JS; Messmer, EM; Pepose, JS; Sangwan, VS; Weiner, AL; Wilson, SE; Wolffsohn, JS.
TFOS DEWS II iatrogenic report.
Ocul Surf. 2017; 15(3):511-538
Doi: 10.1016/j.jtos.2017.05.004
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Horwath-Winter Jutta
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- Abstract:
- Dry eye can be caused by a variety of iatrogenic interventions. The increasing number of patients looking for eye care or cosmetic procedures involving the eyes, together with a better understanding of the pathophysiological mechanisms of dry eye disease (DED), have led to the need for a specific report about iatrogenic dry eye within the TFOS DEWS II. Topical medications can cause DED due to their allergic, toxic and immuno-inflammatory effects on the ocular surface. Preservatives, such as benzalkonium chloride, may further aggravate DED. A variety of systemic drugs can also induce DED secondary to multiple mechanisms. Moreover, the use of contact lens induces or is associated with DED. However, one of the most emblematic situations is DED caused by surgical procedures such as corneal refractive surgery as in laser-assisted in situ keratomileusis (LASIK) and keratoplasty due to mechanisms intrinsic to the procedure (i.e. corneal nerve cutting) or even by the use of postoperative topical drugs. Cataract surgery, lid surgeries, botulinum toxin application and cosmetic procedures are also considered risk factors to iatrogenic DED, which can cause patient dissatisfaction, visual disturbance and poor surgical outcomes. This report also presents future directions to address iatrogenic DED, including the need for more in-depth epidemiological studies about the risk factors, development of less toxic medications and preservatives, as well as new techniques for less invasive eye surgeries. Novel research into detection of early dry eye prior to surgeries, efforts to establish appropriate therapeutics and a greater attempt to regulate and oversee medications, preservatives and procedures should be considered. Copyright © 2017 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Contact Lenses -
- Dry Eye Syndromes -
- Humans -
- Iatrogenic Disease -
- Keratoconjunctivitis Sicca -
- Keratomileusis, Laser In Situ -
- Find related publications in this database (Keywords)
- Contact lens
- Cosmetic
- Drug related adverse reactions
- Drug related side effects
- Drug toxicity
- Dry eye
- Iatrogenic disease
- Surgery