Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kovacs, G; Avian, A; Wutte, N; Hafner, F; Moazedi-Fürst, F; Kielhauser, S; Aberer, E; Brodmann, M; Graninger, W; Foris, V; Olschewski, A; Olschewski, H.
Changes in pulmonary exercise haemodynamics in scleroderma: a 4-year prospective study.
Eur Respir J. 2017; 50(1):
Doi: 10.1183/13993003.01708-2016
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- Führende Autor*innen der Med Uni Graz
- Kovacs Gabor
- Co-Autor*innen der Med Uni Graz
- Aberer Elisabeth
- Avian Alexander
- Brodmann Marianne
- Foris Vasile
- Graninger Winfried
- Hafner Franz
- Kielhauser Sonja
- Moazedi-Fürst Florentine
- Olschewski Andrea
- Olschewski Horst
- Palfner-Wutte Nora Johanna
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- Abstract:
- Pulmonary arterial hypertension (PAH) is a feared complication of systemic sclerosis. In this prospective cohort study, we monitored the changes in resting and exercise pulmonary haemodynamics of scleroderma patients without initial PAH over a mean follow-up period of ∼4 years.All patients underwent exercise echocardiography and cardiopulmonary exercise testing at baseline and follow-up. A subgroup underwent exercise right heart catheter (RHC) investigations. The primary end-point was the echocardiographic systolic pulmonary arterial pressure at 50 W exercise (sPAP50).We included 99 patients, of whom 58 had a complete dataset. Three out of 99 patients developed RHC-confirmed PAH (0.75 cases per 100 patient-years). sPAP50 increased (p<0.001) and peak oxygen uptake (secondary end-point) decreased significantly (p=0.001) during follow-up, but there was no significant change in resting sPAP (p=0.38). In the RHC subgroup (n=28), mean (m)PAP and pulmonary vascular resistance at 50 W increased significantly (p=0.02 and p=0.002, respectively), but resting mPAP was unchanged.Scleroderma patients without PAH develop a mild but significant deterioration of pulmonary exercise haemodynamics and exercise capacity over a 4-year follow-up period, indicating a progression of pulmonary vascular disease. The manifestation rate of RHC-confirmed PAH was 0.75 cases per 100 patient-years. Copyright ©ERS 2017.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Austria -
- Blood Pressure -
- Cardiac Output -
- Echocardiography -
- Exercise -
- Exercise Test -
- Female -
- Humans -
- Hypertension, Pulmonary - physiopathology
- Male -
- Middle Aged -
- Prospective Studies -
- Pulmonary Artery - physiopathology
- Rest -
- Scleroderma, Systemic - complications
- Vascular Resistance -