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SHR Neuro Cancer Cardio Lipid Metab Microb

Kadletz, L; Heiduschka, G; Wolf, A; Haug-Lettenbichler, A; Poyntner, L; Primosch, T; Rogatsch, H; Formanek, M; Stadler, M; Kenner, L; Eckel, HE; Brunner, M.
Effect of postoperative radiotherapy in pT1pN1cM0 and pT2p/cN0cM0 oropharyngeal squamous cell carcinoma.
Laryngoscope. 2018; 128(5):1075-1082 Doi: 10.1002/lary.26815 [OPEN ACCESS]
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Co-authors Med Uni Graz: Wolf Axel
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Abstract:: Consulting of patients with oropharyngeal carcinoma, classified as pT1pN1cM0 and pT2p/cN0cM0, about postoperative radiotherapy is a precarious task as data are lacking. The aim of this study was to evaluate the effects of postoperative radiotherapy for patients with intermediate-stage oropharyngeal carcinoma. Multicentric retrospective study. This analysis was conducted at seven Austrian institutions and included data of patients treated between 2000 and 2012. A total of 81 patients with oropharyngeal squamous cell carcinoma were included, of whom 33 patients received postoperative radiotherapy. p16 status determined by immunohistochemistry was available in 68 patients. Median follow-up was 47.9 months. Postoperative radiotherapy showed no benefits in regard to overall survival (P = .701). In contrast, disease-free survival was significantly shortened in all patients without postoperative radiotherapy (P = .001). When dividing the cohort in dependence of p16, p16-positive patients did not benefit from postoperative radiotherapy regarding overall and disease-free survival (P = .934 and P = .102), whereas p16-negative patients showed improved disease-free survival after postoperative radiotherapy (P = .007). Multivariate analysis showed that outcome of postoperative radiotherapy is dependent on p16 status. In terms of disease-free survival, patients with p16-negative tumors may benefit from postoperative radiotherapy, whereas survival of p16-positive patients is good regardless of additional treatment. 4. Laryngoscope, 128:1075-1082, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Austria -; Carcinoma, Squamous Cell - radiotherapy; Carcinoma, Squamous Cell - surgery; Cyclin-Dependent Kinase Inhibitor p16 - analysis; Female -; Humans -; Immunohistochemistry -; Male -; Middle Aged -; Neoplasm Staging -; Oropharyngeal Neoplasms - radiotherapy; Oropharyngeal Neoplasms - surgery; Retrospective Studies -; Survival Rate -; Treatment Outcome -
Find related publications in this database (Keywords): Oropharyngeal carcinoma; T1N1; T2N0; adjuvant radiotherapy; postoperative radiotherapy; survival