Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Herrmann, M; Müller, M; Scharhag, J; Sand-Hill, M; Kindermann, W; Herrmann, W.
The effect of endurance exercise-induced lactacidosis on biochemical markers of bone turnover.
Clin Chem Lab Med. 2007; 45(10):1381-1389
Doi: 10.1515/CCLM.2007.282
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Herrmann Markus
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- Abstract:
- Stress fractures are frequent injuries among athletes. In vitro, decreases in pH stimulate osteoclasts and inhibit osteoblasts. We hypothesized that exercise-induced lactacidosis stimulates osteoclasts and reduces osteoblast activity in vivo. A total of 32 volunteers (MA, male athletes; MCo, male controls; female athletes; and female controls) performed three 60-min cycle ergometer tests at 75%, 95% and 110% of their individual anaerobic threshold (IAT). Blood was taken before and at 3 and 24 h after exercise. Osteocalcin (OC), pro-collagen type I N-terminal peptide (PINP), C-terminal telopeptides of collagen I (CTx) and tartrate-resistant acid phosphatase (TRAP) were measured. At 75% and 95% IAT, pH did not change. At 110% IAT, pH decreased in MA by 0.08 units (p=0.041) and in MCo by 0.03 units (p=0.017). The pH results were substantiated by circulating lactate concentrations. The bone resorption markers TRAP and CTx were not consistently modified by any of the exercise tests. Exercise at 75% decreased OC and PINP in all groups. Exercise at 95% and 110% did not induce homogeneous effects. Anaerobic exercise does not systemically affect bone turnover, suggesting that exercise-induced acidosis is not involved in the pathogenesis of stress fractures.
- Find related publications in this database (using NLM MeSH Indexing)
- Acid Phosphatase - blood
- Acidosis, Lactic - pathology
- Adult -
- Biomarkers - blood
- Bone and Bones - metabolism
- Collagen Type I - blood
- Exercise - physiology
- Female -
- Humans -
- Hydrogen-Ion Concentration -
- Isoenzymes - blood
- Male -
- Osteocalcin - blood
- Peptide Fragments - blood
- Physical Endurance - physiology
- Procollagen - blood
- Tartrate-Resistant Acid Phosphatase -
- Time Factors -
- Find related publications in this database (Keywords)
- acidosis
- bone turnover markers
- lactate