Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Herrmann, M; Müller, S; Kindermann, I; Günther, L; König, J; Böhm, M; Herrmann, W.
Plasma B vitamins and their relation to the severity of chronic heart failure.
Am J Clin Nutr. 2007; 85(1):117-123
Doi: 10.1093/ajcn/85.1.117
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Herrmann Markus
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- Abstract:
- Total homocysteine (tHcy) has been linked to the severity of chronic heart failure (CHF). Elevated tHcy concentrations are mainly caused by folate and vitamin B-12 deficiencies. We hypothesized that folate and vitamin B-12 deficiencies can explain the relation between tHcy and the severity of CHF. We investigated 987 CHF patients. All subjects underwent a physical examination and blood sampling. Cardiac catheterization was performed in 929 patients and echocardiography in 460 patients. Serum tHcy, folate, vitamin B-12, and N-terminal pro-B-type natriuretic-peptide (NT-proBNP) were measured and renal and hepatic function were studied. tHcy increased with increasing New York Heart Association (NYHA) classes of heart failure (P < 0.001) and correlated with the left ventricular ejection fraction (EF; r = -0.150, P < 0.001). Contrary to the hypothesis, vitamin B-12 (P < 0.001) increased with NYHA class (P < 0.001) and was negatively correlated with EF (r = -0.080, P = 0.015). Folate showed no relation with NYHA class or EF. Comparable results were obtained for NT-proBNP (tHcy: r = 0.27, P < 0.001; vitamin B-12: r = 0.091, P = 0.004; folate: r = -0.045, P = 0.169). The correlations between tHcy, EF, and NT-proBNP were significantly stronger in patients without coronary artery disease (CAD) than in those with CAD. Regression analysis showed that tHcy, but not B vitamins, is a strong predictor of EF and NT-proBNP. This study showed that tHcy, but not folate and vitamin B-12, is related to clinical, echocardiographic, and laboratory variables of CHF, which indicates a relation between tHcy and the severity of CHF. This relation is stronger in patients without CAD. The lack of association of folate and the paradoxical relation of vitamin B-12 with CHF can possibly be explained by a disturbance in hepatic homeostasis.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Cardiac Catheterization -
- Echocardiography -
- Female -
- Folic Acid - blood
- Folic Acid Deficiency - blood
- Folic Acid Deficiency - complications
- Heart Failure - blood
- Heart Failure - etiology
- Heart Failure - pathology
- Homocysteine - blood
- Humans -
- Liver - metabolism
- Male -
- Middle Aged -
- Multivariate Analysis -
- Severity of Illness Index -
- Vitamin B 12 - blood
- Vitamin B 12 Deficiency - blood
- Vitamin B 12 Deficiency - complications
- Vitamin B Complex - blood
- Find related publications in this database (Keywords)
- chronic heart failure
- homocysteine
- folate
- vitamin B-12
- NT-proBNP
- ejection fraction
- coronary artery disease