Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holstein, JH; Herrmann, M; Splett, C; Herrmann, W; Garcia, P; Histing, T; Graeber, S; Ong, MF; Kurz, K; Siebel, T; Menger, MD; Pohlemann, T.
Low serum folate and vitamin B-6 are associated with an altered cancellous bone structure in humans.
Am J Clin Nutr. 2009; 90(5):1440-1445
Doi: 10.3945/ajcn.2009.28116
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- Herrmann Markus
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- Abstract:
- Several clinical trials have reported B vitamins to be associated with osteoporosis. Our objective was to investigate whether low serum B vitamins are associated with altered structural and biomechanical properties of human bone. Femoral heads of 94 men and women who underwent hip arthroplasty were analyzed by using dual-energy X-ray absorptiometry (DXA), biomechanical testing (indentation method), and histomorphometry. In addition, blood was collected to measure serum concentrations of homocysteine, folate, vitamin B-6, vitamin B-12, the bone formation marker osteocalcin, and the bone resorption marker tartrate-resistant acid phosphatase (TRAP). Measurement outcomes were grouped according to subjects with high and low serum concentrations, respectively, of folate, vitamin B-6, and vitamin B-12 (n = 47 for each group). Histomorphometric analysis showed a significantly lower trabecular thickness and trabecular area in subjects with low serum folate concentrations than in those with high serum folate concentrations and a significantly lower trabecular number in subjects with low serum vitamin B-6 concentrations than in those with high serum vitamin B-6 concentrations. In contrast, we found a comparable trabecular structure in subjects with high and low serum vitamin B-12 concentrations. DXA and biomechanical testing did not show significant differences between subjects with high and low serum B vitamin concentrations. Osteocalcin was significantly lowered in subjects with a low serum B vitamin concentration, whereas there was no association between serum B vitamins and TRAP. The results of the present study indicate that low serum folate and vitamin B-6 concentrations, but not low serum vitamin B-12 concentrations, are associated with an altered morphology of human bone.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorptiometry, Photon -
- Aged -
- Arthroplasty, Replacement, Hip - methods
- Body Height -
- Body Weight -
- Bone Density -
- Bone and Bones - pathology
- Female -
- Femur Head - pathology
- Folic Acid - blood
- Folic Acid Deficiency - blood
- Humans -
- Male -
- Middle Aged -
- Osteoporosis - blood
- Vitamin B 12 - blood
- Vitamin B 12 Deficiency - blood
- Vitamin B 6 Deficiency - blood