Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Herrmann, M; Tami, A; Wildemann, B; Wolny, M; Wagner, A; Schorr, H; Taban-Shomal, O; Umanskaya, N; Ross, S; Garcia, P; Hübner, U; Herrmann, W.
Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone.
Bone. 2009; 44(3):467-475
Doi: 10.1016/j.bone.2008.10.051
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Herrmann Markus
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- Abstract:
- Recently, hyperhomocysteinemia (HHCY) has been suggested to have adverse effects on bone. This study investigated if an experimental HHCY in rats induces an accumulation of homocysteine (HCY) in bone tissue that is accompanied by bone loss and reduced bone strength. HHCY was induced in healthy rats by either a methionine (Meth)- or a homocystine (Homo)-enriched diet and compared with controls. Homocystine is the product of two disulfide linked HCY molecules. Tissue and plasma concentrations of HCY, S-adenosylhomocysteine (SAH) and S-adenosylmethionine (SAM) were measured. Bones were assessed by biomechanical testing, histomorphometry, microCT and the measurement of biochemical bone turnover markers in plasma. Meth and Homo animals developed a significant HHCY that was accompanied by a tissue specific accumulation of HCY (1300 to 2000% vs. controls). 65% of HCY in bone was bound to collagen of the extracellular matrix. The SAH / SAM-ratio in bone and plasma of Meth and Homo animals exhibited a tissue specific increase indicating a reduced methylation capacity. Accumulation of HCY in bone was characterized by a distinct reduction of cancellous bone (proximal femur: -25 to -35%; distal femur -56 to -58%, proximal tibia: -28 to -43%). Accordingly, bone strength was significantly reduced (-9 to -12%). A tissue specific accumulation of HCY in bone may be a promising mechanism explaining adverse effects of HHCY on bone. A reduced methylation capacity of bone cells might be another relevant pathomechanism.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Animals -
- Bone and Bones - anatomy & histology
- Bone and Bones - chemistry
- Bone and Bones - metabolism
- Bone and Bones - pathology
- Collagen - metabolism
- Female -
- Homocysteine - metabolism
- Homocystine - administration & dosage
- Humans -
- Hyperhomocysteinemia - chemically induced
- Hyperhomocysteinemia - metabolism
- Male -
- Methionine - administration & dosage
- Myocardium - chemistry
- Osteoporosis - metabolism
- Porosity -
- Rats -
- Rats, Wistar -
- S-Adenosylhomocysteine - metabolism
- S-Adenosylmethionine - metabolism
- Stress, Mechanical -
- Find related publications in this database (Keywords)
- Homocysteine
- Osteoporosis
- Bone
- S-adenosylhomocysteine
- S-adenosylmethionine