Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Scharhag, J; Meyer, T; Auracher, M; Müller, M; Herrmann, M; Gabriel, H; Herrmann, W; Kindermann, W.
Exercise-induced increases in NT-proBNP are not related to the exercise-induced immune response.
Br J Sports Med. 2008; 42(5):383-385
Doi: 10.1136/bjsm.2007.039529
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Herrmann Markus
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- Abstract:
- To investigate if the exercise-induced immune response contributes to the exercise-induced increase in brain natriuretic peptide (BNP) in healthy athletes. This has previously been speculated, as elevated concentrations of BNP or N-terminal pro brain natriuretic peptide (NT-proBNP) in cardiovascular patients were found to be related to immune reactions and elevations in inflammatory cytokines such as interleukin 6 (IL-6). Stored serum samples were analysed for NT-proBNP concentrations of 14 healthy endurance athletes (mean age: 25 (SD 5) years; VO(2peak) 67 (SD 6) ml/min/kg), who had been examined previously for exercise-induced immune reactions and their dependence on carbohydrate supplementation (6 or 12% carbohydrate vs placebo beverages) after three bouts of 4 h cycling at a given workload of 70% of the individual anaerobic threshold. Venous blood samples were taken before, immediately after, and 1 h and 1 day after exercise. Leucocyte subpopulations were determined immediately after blood sampling by flow cytometry. Serum samples for posterior analysis of C-reactive protein (CRP), IL-6, cortisol and NT-proBNP were stored at -80 degrees C. The exercise-induced increases in NT-proBNP (p<0.001) were not related to the exercise-induced immune response, although exercise induced marked (CHOS-dependent) increases in IL-6, CRP, cortisol, leucocytes, neutrophils, monocytes and natural killer cells. It is unlikely that the exercise-induced increases in NT-proBNP or BNP in healthy athletes are caused by the exercise-induced immune response. Therefore, exercise-induced increases in NT-proBNP or BNP in healthy athletes have to be differentiated from increases in cardiovascular patients with systemic inflammation.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Enzyme-Linked Immunosorbent Assay -
- Exercise - physiology
- Flow Cytometry -
- Humans -
- Leukocytes - immunology
- Natriuretic Peptide, Brain - metabolism
- Peptide Fragments - metabolism
- Physical Endurance - physiology
- Sports - physiology