Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Widmann, T; Kneer, H; König, J; Herrmann, M; Pfreundschuh, M.
Sustained telomere erosion due to increased stem cell turnover during triple autologous hematopoietic stem cell transplantation.
Exp Hematol. 2008; 36(1):104-110
Doi: 10.1016/j.exphem.2007.08.028
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Herrmann Markus
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- Abstract:
- Telomeres cap chromosomal ends and are shortened throughout a lifetime. Additional telomere erosion has been documented during conventional chemotherapy or hematopoietic stem cell transplantation. Previous studies of stem cell transplantation reported variable amounts of telomere shortening with inconsistent results regarding the persistence of telomere shortening. Here we have prospectively studied telomere length and proliferation kinetics of hematopoietic cells in aggressive non-Hodgkin lymphoma patients who underwent a four-course high-dose chemotherapy protocol combined with triple autologous stem cell transplantation. We observed sustained telomere shortening in hematopoietic cells after triple stem cell transplantation with prolonged stem cell replication during the first year after stem cell transplantation.
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- Antibodies, Monoclonal - administration & dosage
- Antibodies, Monoclonal, Murine-Derived -
- Antineoplastic Combined Chemotherapy Protocols - administration & dosage
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- Cell Aging -
- Cell Division -
- Clinical Trials, Phase III as Topic -
- Combined Modality Therapy -
- Cyclophosphamide - administration & dosage
- Doxorubicin - administration & dosage
- Drug Administration Schedule -
- Etoposide - administration & dosage
- Female -
- Granulocyte Colony-Stimulating Factor - administration & dosage
- Granulocytes - drug effects
- Granulocytes - ultrastructure
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- Lymphocytes - drug effects
- Lymphocytes - ultrastructure
- Lymphoma, Non-Hodgkin - drug therapy
- Lymphoma, Non-Hodgkin - pathology
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- Myeloablative Agonists - pharmacology
- Myelopoiesis - drug effects
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- Peripheral Blood Stem Cell Transplantation - adverse effects
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