Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Herrmann, M; Wildemann, B; Claes, L; Klohs, S; Ohnmacht, M; Taban-Shomal, O; Hübner, U; Pexa, A; Umanskaya, N; Herrmann, W.
Experimental hyperhomocysteinemia reduces bone quality in rats.
Clin Chem. 2007; 53(8):1455-1461
Doi: 10.1373/clinchem.2007.086272
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- Herrmann Markus
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- Abstract:
- Recently, hyperhomocysteinemia (HHCY) has been suggested as a new risk factor for osteoporosis. This study investigated if HHCY is a causal osteoporotic factor in vivo. We used 3 groups of rats: a control group (n = 20), a moderate HHCY group (induced by a 2.4% methionine-enriched diet, n = 10), and an intermediate HHCY group (induced by a 2% homocystine-enriched diet, n = 10). We measured bone fragility [maximum force of an axial compression test (F(max))], bone area as percentage of total area (BAr/TAr, histomorphometry), and biochemical bone turnover markers [osteocalcin (OC) and collagen I C-terminal crosslaps (CTx)]. Compared with controls, 3 months of moderate or intermediate HHCY increased mean (SD) bone fragility at the femoral neck by 18% (6%) in methionine-fed (P = 0.001) and 36% (13%) in homocystine-fed rats (P <0.001). Mean (SD) BAr/TAr at the distal femur in methionine and homocystine groups was decreased by 45% (21%; P = 0.001) and 93% (9%; P = 0.001), respectively. At the femoral neck, BAr/TAr was decreased by 19% (11%; P <0.001) and 55% (19%; P <0.001). At the lumbar spine, the reduction of BAr/TAr was 17% (23%; P = 0.099) and 44% (19%; P <0.001). Plasma OC (bone formation marker) was decreased by 23% (20%; P = 0.006) and 34% (21%; P <0.001). Plasma CTx (bone resorption marker) did not differ between groups. Bone quality is consistently decreased in the presence of increased circulating homocysteine. The results provide evidence that HHCY is a causal osteoporotic factor.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biomarkers - blood
- Compressive Strength -
- Female -
- Femoral Fractures - etiology
- Femoral Fractures - pathology
- Femoral Fractures - physiopathology
- Femur - metabolism
- Femur - pathology
- Femur - physiopathology
- Fractures, Compression - etiology
- Fractures, Compression - pathology
- Fractures, Compression - physiopathology
- Hyperhomocysteinemia - complications
- Hyperhomocysteinemia - metabolism
- Hyperhomocysteinemia - pathology
- Hyperhomocysteinemia - physiopathology
- Osteogenesis -
- Osteoporosis - etiology
- Rats -
- Rats, Wistar -
- Risk Factors -