Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Paar, M; Rossmann, C; Nusshold, C; Wagner, T; Schlagenhauf, A; Leschnik, B; Oettl, K; Koestenberger, M; Cvirn, G; Hallström, S.
Anticoagulant action of low, physiologic, and high albumin levels in whole blood.
PLoS One. 2017; 12(8):e0182997-e0182997
Doi: 10.1371/journal.pone.0182997
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- Führende Autor*innen der Med Uni Graz
- Cvirn Gerhard
- Paar Margret
- Co-Autor*innen der Med Uni Graz
- Hallström Seth
- Koestenberger Martin
- Leschnik Bettina
- Nusshold Christoph
- Öttl Karl
- Rossmann Christine Renate
- Schlagenhauf Axel
- Wagner Thomas
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- Abstract:
- Albumin is the most abundant plasma protein. Critical illness is often associated with altered, predominately decreased, serum albumin levels. This hypoalbuminaemia is usually corrected by administration of exogenous albumin. This study aimed to track the concentration-dependent influence of albumin on blood coagulation in vitro. Whole blood (WB) samples from 25 volunteers were prepared to contain low (19.3 ± 7.7 g/L), physiological (45.2 ± 7.8 g/L), and high (67.5 ± 18.1 g/L) levels of albumin. Haemostatic profiling was performed using a platelet function analyzer (PFA) 200, impedance aggregometry, a Cone and Platelet analyzer (CPA), calibrated automated thrombogram, and thrombelastometry (TEM). Platelet aggregation-associated ATP release was assessed via HPLC analysis. In the low albumin group, when compared to the physiological albumin group, we found: i) shortened PFA 200-derived closure times indicating increased primary haemostasis; ii) increased impedance aggregometry-derived amplitudes, slopes, ATP release, as well as CPA-derived average size indicating improved platelet aggregation; iii) increased TEM-derived maximum clot firmness and alpha angles indicating enhanced clot formation. TEM measurements indicated impaired clot formation in the high albumin group compared with the physiological albumin group. Thus, albumin exerted significant anticoagulant action. Therefore, low albumin levels, often present in cancer or critically ill patients, might contribute to the frequently occurring venous thromboembolism.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticoagulants - pharmacology
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- Blood Platelets - cytology
- Blood Platelets - drug effects
- Blood Platelets - physiology
- Cells, Cultured -
- Female -
- Humans -
- Male -
- Platelet Aggregation - drug effects
- Platelet Function Tests -
- Serum Albumin - pharmacology