Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Perakis, S; Auer, M; Belic, J; Heitzer, E.
Advances in Circulating Tumor DNA Analysis.
Adv Clin Chem. 2017; 80(10):73-153
Doi: 10.1016/bs.acc.2016.11.005
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hasenleithner Samantha
- Heitzer Ellen
- Co-Autor*innen der Med Uni Graz
- Auer Martina
- Belic Jelena
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- Abstract:
- The analysis of cell-free circulating tumor DNA (ctDNA) is a very promising tool and might revolutionize cancer care with respect to early detection, identification of minimal residual disease, assessment of treatment response, and monitoring tumor evolution. ctDNA analysis, often referred to as "liquid biopsy" offers what tissue biopsies cannot-a continuous monitoring of tumor-specific changes during the entire course of the disease. Owing to technological improvements, efforts for the establishment of preanalytical and analytical benchmark, and the inclusion of ctDNA analyses in clinical trial, an actual clinical implementation has come within easy reach. In this chapter, recent advances of the analysis of ctDNA are summarized starting from the discovery of cell-free DNA, to methodological approaches and the clinical applicability. © 2017 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor - blood
- Biomarkers, Tumor - genetics
- DNA, Neoplasm - blood
- DNA, Neoplasm - genetics
- Genetic Markers -
- Humans -
- Mutation -
- Neoplasms - diagnosis
- Neoplasms - genetics
- Predictive Value of Tests -