Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ehrlich, L; Hoeller, A; Golic, M; Herse, F; Perschel, FH; Henrich, W; Dechend, R; Huppertz, B; Verlohren, S.
Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia.
Hypertens Pregnancy. 2017; 36(2):175-185
Doi: 10.1080/10641955.2017.1291673
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased. High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Case-Control Studies -
- Female -
- Fetal Growth Retardation - blood
- Humans -
- Placenta - metabolism
- Placenta Growth Factor - blood
- Pre-Eclampsia - blood
- Pregnancy -
- Vascular Endothelial Growth Factor Receptor-1 - blood
- Young Adult -
- Find related publications in this database (Keywords)
- Preeclampsia
- intra uterine growth restriction
- placental growth factor
- PlGF
- souble fms-like tyrosine kinase
- sFlt1