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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Drobnjak, T; Gizurarson, S; Gokina, NI; Meiri, H; Mandalá, M; Huppertz, B; Osol, G.
Placental protein 13 (PP13)-induced vasodilation of resistance arteries from pregnant and nonpregnant rats occurs via endothelial-signaling pathways.
Hypertens Pregnancy. 2017; 36(2):186-195 Doi: 10.1080/10641955.2017.1295052 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz: Huppertz Berthold
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Abstract:: Placental protein 13 (PP13) induces hypotension in rats. This study aims to evaluate PP13 effects on isolated uterine arteries from nonpregnant and mid-pregnant rats. Vessels were isolated, cannulated, and pressurized to 50 mmHg within an arteriograph, preconstricted and exposed to increasing PP13 concentrations (10^-13-10^-8 M). PP13 elicited 38-50% arterial vasodilation with half-maximum response (EC₅₀) = 1 pM. The relaxation was mediated by activating the endothelial-signaling pathways of prostaglandin and nitric oxide (NO). Accordingly, these results encourage evaluation of PP13 as a possible therapy for gestational diseases characterized by insufficient uteroplacental blood flow and/or maternal hypertension.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Benzyl Compounds -; Calcium - metabolism; Cyclooxygenase 1 - metabolism; Cyclooxygenase 2 - metabolism; Endothelium, Vascular - metabolism; Female -; Galectins - physiology; Imidazoles -; Membrane Proteins - metabolism; Nitric Oxide Synthase - metabolism; Pregnancy -; Pregnancy Proteins - physiology; Pregnancy, Animal - physiology; Rats -; Rats, Sprague-Dawley -; Uterine Artery - physiology; Vasodilation -
Find related publications in this database (Keywords): eNOS; prostacyclin (PGI(2)); uterine vasculature; endothelial layers; preeclampsia