Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Cserni, G; Floris, G; Koufopoulos, N; Kovács, A; Nonni, A; Regitnig, P; Stahls, A; Varga, Z.
Invasive lobular carcinoma with extracellular mucin production-a novel pattern of lobular carcinomas of the breast. Clinico-pathological description of eight cases.
Virchows Arch. 2017; 471(1):3-12
Doi: 10.1007/s00428-017-2147-6
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- Co-Autor*innen der Med Uni Graz
- Regitnig Peter
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- Abstract:
- Invasive lobular carcinoma of the breast is known to produce intracellular mucin and has been recognized in single-case reports to show extracellular mucin production, as well. This latter morphology is not only rare but must also be under- or misdiagnosed. The aim was to better characterize this entity. Cases of lobular cancers demonstrating extracellular mucin formation were identified in a multi-institutional effort and their clinical and morphologic features were assessed. Immunohistochemistry was used to characterize the E-cadherin-membrane complex, neuroendocrine differentiation, and to some extent, mucin formation. All but one of the eight cases occurred in postmenopausal patients. Extracellular mucin production was present in 5 to 50% of the tumour samples and rarely also appeared in nodal and distant metastases. The tumours were completely E-cadherin negative and showed cytoplasmic p120 positivity. The majority (n = 6/8) was also completely negative for β-catenin, but two tumours displayed focal β-catenin positivity in the mucinous area. MUC1 and MUC2 expression was observed in all and 7/8 tumours, respectively; neuroendocrine differentiation was present in only one. Invasive lobular carcinoma with extracellular mucin formation is a rare morphologic variant of lobular carcinoma prone to be misdiagnosed and warranting further studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biomarkers, Tumor - analysis
- Breast Neoplasms - metabolism
- Breast Neoplasms - pathology
- Carcinoma, Lobular - metabolism
- Carcinoma, Lobular - pathology
- Female -
- Humans -
- Middle Aged -
- Mucin-1 - biosynthesis
- Mucin-2 - biosynthesis
- Find related publications in this database (Keywords)
- Breast cancer
- E-cadherin
- Extracellular mucin
- Lobular carcinoma
- Mucinous carcinoma