Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wonisch, M; Lercher, P; Scherr, D; Maier, R; Pokan, R; Hofmann, P; von Duvillard, SP.
Influence of permanent right ventricular pacing on cardiorespiratory exercise parameters in chronic heart failure patients with implanted cardioverter defibrillators.
Chest. 2005; 127(3):787-793
Doi: 10.1378/chest.127.3.787
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Wonisch Manfred
- Co-authors Med Uni Graz
- Lercher Peter
- Maier Robert
- Scherr Daniel
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Patients with chronic heart failure and implanted cardioverter-defibrillators (ICDs) may have a higher incidence of new-onset or worsening heart failure requiring hospitalization with dual-chamber ICDs compared with single-chamber ICDs. The purpose of this study was to show the impact of permanent right ventricular (RV) pacing on exercise capacity and related cardiorespiratory parameters in patients with chronic heart failure and ICDs. Seventeen patients with chronic heart failure and a dual-chamber ICD performed cardiopulmonary exercise testing (CPX) on 3 different days. After CPX 1, patients were randomized either to back-up pacing or permanent RV pacing. After 3 months, CPX 2 was performed and patients changed groups (crossover design); CPX 3 was performed after 3 additional months. Maximal values for workload (108 +/- 46 W vs 117 +/- 48 W, p < 0.01), oxygen uptake (Vo(2)) [21.0 +/- 5.3 mL/min/kg vs 22.5 +/- 6.4 mL/min/kg, p < 0.05], oxygen pulse (13 +/- 3.7 mL vs 14 +/- 4.0 mL, p < 0.05), and metabolic equivalent (6.0 +/- 1.5 vs 6.4 +/- 1.8, p < 0.05) were significantly lower with permanent RV pacing compared to back-up pacing. Workload, Vo(2), and oxygen pulse were significantly reduced at the ventilatory anaerobic threshold, while workload and Vo(2) were significantly lower at the respiratory compensation point. No differences were found for maximal heart rate, minute ventilation Ve, and respiratory exchange ratio. The Ve/carbon dioxide production slope was significantly steeper with permanent RV pacing compared to back-up pacing. Permanent RV pacing significantly reduced maximal and submaximal measures of exercise. For patients with chronic heart failure and sufficient atrioventricular conduction, every effort should be made to minimize permanent right ventricular pacing.
- Find related publications in this database (using NLM MeSH Indexing)
- Anaerobic Threshold -
- Chronic Disease -
- Cross-Over Studies -
- Defibrillators, Implantable -
- Double-Blind Method -
- Exercise Test -
- Female -
- Heart Failure - physiopathology
- Heart Failure - therapy
- Humans -
- Male -
- Middle Aged -
- Oxygen Consumption -
- Pacemaker, Artificial - adverse effects
- Pulmonary Gas Exchange -
- Pulmonary Ventilation -
- Find related publications in this database (Keywords)
- cardiopulmonary exercise testing
- dual-chamber implantable cardioverter defibrillator
- maximal oxygen consumption
- minute ventilation/carbon dioxide production slope
- respiratory compensation point
- ventilatory anaerobic threshold
- ventilatory efficiency