Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rohban, R; Prietl, B; Pieber, TR.
Crosstalk between Stem and Progenitor Cellular Mediators with Special Emphasis on Vasculogenesis
TRANSFUS MED HEMOTH. 2017; 44(3): 174-182.
Doi: 10.1159/000477677
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- Führende Autor*innen der Med Uni Graz
- Rohban Rokhsareh
- Co-Autor*innen der Med Uni Graz
- Pieber Thomas
- Prietl Barbara
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- Abstract:
- The cellular components and molecular processes of signaling during vasculogenesis have been investigated for decades. Considerable efforts have been made to unravel regulatory mechanisms of vasculogenesis through crosstalk between vasculogenic playmakers located in the vascular niche, namely hematopoietic stem cells, endothelial progenitor cells, and mesenchymal stem and progenitor cells. Recent studies have increased the knowledge about signaling events within vascular microenvironment that leads to vasculogenesis. Findings from these recent studies indicate the impact of cellular crosstalk through signaling pathways such as vascular endothelial growth factor signaling, wingless and Notch signaling in vasculogenesis and vascular development. In this review, we highlight the signaling signature between stem and progenitor cellular mediators during vasculogenesis. We further focus on hematopoietic stem cell-endothelial progenitor cell crosstalk during vasculogenesis and discuss their potential implications and benefits for therapeutic interventions and regenerative therapy.
- Find related publications in this database (Keywords)
- Hematopoietic stem cells
- Stem cells
- Transplantation
- Endothelial progenitors
- Signaling
- Crosstalk
- Vasculogenesis
- Regeneration
- Therapy