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SHR Neuro Cancer Cardio Lipid Metab Microb

Moissl-Eichinger, C; Probst, AJ; Birarda, G; Auerbach, A; Koskinen, K; Wolf, P; Holman, HN.
Human age and skin physiology shape diversity and abundance of Archaea on skin.
Sci Rep. 2017; 7(1):4039-4039 Doi: 10.1038/s41598-017-04197-4 [OPEN ACCESS]
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Leading authors Med Uni Graz: Moissl-Eichinger Christine
Co-authors Med Uni Graz: Koskinen Mora Kaisa; Wolf Peter
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Abstract:: The human skin microbiome acts as an important barrier protecting our body from pathogens and other environmental influences. Recent investigations have provided evidence that Archaea are a constant but highly variable component of the human skin microbiome, yet factors that determine their abundance changes are unknown. Here, we tested the hypothesis that the abundance of archaea on human skin is influenced by human age and skin physiology by quantitative PCR of 51 different skin samples taken from human subjects of various age. Our results reveal that archaea are more abundant in human subjects either older than 60 years or younger than 12 years as compared to middle-aged human subjects. These results, together with results obtained from spectroscopy analysis, allowed us gain first insights into a potential link of lower sebum levels and lipid content and thus reduced skin moisture with an increase in archaeal signatures. Amplicon sequencing of selected samples revealed the prevalence of specific eury- and mainly thaumarchaeal taxa, represented by a core archaeome of the human skin.
Find related publications in this database (using NLM MeSH Indexing): Age Factors -; Archaea - classification; Archaea - genetics; Biodiversity -; Female -; High-Throughput Nucleotide Sequencing -; Humans -; Male -; Microbiota -; Middle Aged -; Phylogeny -; RNA, Ribosomal, 16S -; Skin - microbiology; Skin Physiological Phenomena -; Spectroscopy, Fourier Transform Infrared -