Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moinfar, F; Gogg-Kamerer, M; Sommersacher, A; Regitnig, P; Man, YG; Zatloukal, K; Denk, H; Tavassoli, FA.
Endometrial stromal sarcomas frequently express epidermal growth factor receptor (EGFR, HER-1): potential basis for a new therapeutic approach.
AMER J SURG PATHOL. 2005; 29(4): 485-489.
Doi: 10.1097%2F01.pas.0000155149.83541.24
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- Führende Autor*innen der Med Uni Graz
- Moinfar Farid
- Co-Autor*innen der Med Uni Graz
- Denk Helmut
- Regitnig Peter
- Zatloukal Kurt
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- Abstract:
- Endometrial stromal sarcomas are rare malignant mesenchymal uterine tumors. The expressions of different epidermal growth factor receptors such as EGFR (HER-1), HER-2, HER-3, and HER-4 have not yet been examined in these tumors. Twenty-three cases of endometrial sarcomas consisting of 20 low-grade endometrial stromal sarcomas and 3 undifferentiated endometrial sarcomas were examined immunohistochemically for EGFR (HER-1), HER-2, HER-3, and HER-4. EGFR (HER-1) was positive in 17 of 23 (74%) cases. While the three undifferentiated endometrial sarcomas were positive for EGFR, 14 of 20 (70%) low-grade endometrial stromal sarcomas showed positive reactions for EGFR. All examined cases were negative for HER-2, HER-3, and HER-4. This study is the first to show common expression of EGFR (HER-1) in endometrial stromal sarcomas. This finding may provide the basis for a new therapeutic strategy using monoclonal antibodies against EGFR (such as cetuximab) or small molecule inhibitors of EGFR (such as gefitinib) in patients with endometrial sarcomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Endometrial Neoplasms - metabolism
- Female - metabolism
- Humans - metabolism
- Immunohistochemistry - metabolism
- Receptor, Epidermal Growth Factor - metabolism
- Retrospective Studies - metabolism
- Sarcoma, Endometrial Stromal - metabolism
- Tumor Markers, Biological - metabolism
- Find related publications in this database (Keywords)
- epidermal growth factor receptor
- EGFR (HER-1)
- endometrial stromal sarcoma
- undifferentiated endometrial sarcoma
- immunohistochemical expression analysis