Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Dumitrescu, D; Nagel, C; Kovacs, G; Bollmann, T; Halank, M; Winkler, J; Hellmich, M; Grünig, E; Olschewski, H; Ewert, R; Rosenkranz, S.
Cardiopulmonary exercise testing for detecting pulmonary arterial hypertension in systemic sclerosis.
Heart. 2017; 103(10):774-782 Doi: 10.1136/heartjnl-2016-309981
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Kovacs Gabor; Olschewski Horst
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Pulmonary arterial hypertension (PAH) is a devastating disease with limited survival and occurs as a frequent complication in patients with systemic sclerosis (SSc). A definite diagnosis of PAH is obtained by right heart catheterisation (RHC); however, the initial suspicion is raised by non-invasive methods. We assessed the diagnostic accuracy of key parameters derived from cardiopulmonary exercise testing (CPET) for detecting and ruling out SSc-associated PAH. In a multicentre setting, we prospectively evaluated 173 consecutive patients with SSc without known PAH, but with clinical suspicion of PAH. Each patient underwent CPET and RHC. RHC identified PAH in 48 patients (27.8%), postcapillary pulmonary hypertension (PH) in 10 patients (5.8%) and ruled out PH in 115 patients (66.5%). CPET parameters correlated significantly with pulmonary haemodynamics. PeakVO₂ and VE/VCO₂ showed highest correlations with pulmonary arterial pressure, transpulmonary pressure gradient and pulmonary vascular resistance. Several parameters showed high sensitivity and specificity for PAH detection by receiver operating characteristic analysis. However, peakVO₂ showed highest diagnostic accuracy (sensitivity 87.5%, specificity 74.8% at a threshold level of 13.8 mL/min/kg). A peakVO₂ of >18.7 mL/kg/min was reached by 38/173 patients (22%) and excluded PAH in our cohort (negative predictive value 1.0). A nadir VE/VCO₂ ratio of >45.5 showed a positive predictive value of 1.0. Diagnostic accuracy was highest in patients with low pulmonary arterial wedge pressure (<12 mm Hg). There were no study-related serious adverse events. CPET is a safe and valuable method in the non-invasive detection of SSc-associated PAH. It may be particularly beneficial for reducing unnecessary RHC procedures. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Algorithms -; Cardiac Catheterization - methods; Echocardiography -; Exercise Test - methods; Female -; Follow-Up Studies -; Humans -; Hypertension, Pulmonary - diagnosis; Hypertension, Pulmonary - etiology; Hypertension, Pulmonary - physiopathology; Male -; Middle Aged -; Prospective Studies -; ROC Curve -; Reproducibility of Results -; Scleroderma, Systemic - complications; Scleroderma, Systemic - diagnosis; Vascular Resistance - physiology; Ventricular Function, Right - physiology