Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Feigl, B; Brown, B; Lovie-Kitchin, J; Swann, P.
Cone- and rod-mediated multifocal electroretinogram in early age-related maculopathy.
Eye. 2005; 19(4):431-441
Doi: 10.1038/sj.eye.6701503
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Feigl Beatrix
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- PURPOSE: To investigate the cone- and rod-mediated multifocal electroretinograms (mfERG) in early age-related maculopathy (early ARM). METHODS AND SUBJECTS: We investigated the cone- and rod-mediated mfERG in 17 eyes of 17 subjects with early ARM and 16 eyes of 16 age-matched control subjects with normal fundi. All subjects had a visual acuity of 6/12 or better. We divided the ARM subjects into two groups based on drusen size and retinal pigment epithelium abnormalities-a less advanced (ARM1) and a more advanced (ARM2) group. The mfERG data were compared to templates derived from the control group. We analysed the mfERG results for the central and peripheral fields (CP method) and the superior and inferior fields (SI method). RESULTS: While the mean cone results showed no statistically significant difference between the groups, the rods showed significantly delayed responses in the ARM1 group for the CP and the SI methods, but not in the ARM2 group, although there was a trend of longer latencies compared to the control group. CONCLUSION: Our results show a functional impairment of the rods in early ARM subjects. As there is histopathological evidence showing earlier rod than cone impairment in early ARM, following the rod function with the mfERG might be helpful in diagnosis or for monitoring the progression of early ARM.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Analysis of Variance -
- Case-Control Studies -
- Cones (Retina) - physiopathology
- Disease Progression - physiopathology
- Electroretinography - physiopathology
- Female - physiopathology
- Humans - physiopathology
- Macular Degeneration - pathology
- Male - pathology
- Middle Aged - pathology
- Pigment Epithelium of Eye - pathology
- Reaction Time - pathology
- Retinal Drusen - pathology
- Rods (Retina) - physiopathology
- Severity of Illness Index - physiopathology
- Visual Acuity - physiopathology
- Find related publications in this database (Keywords)
- multifocal electroretinogram
- MfERG
- cones
- rods
- early age-related maculopathy
- early ARM