Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Haberlandt, E; Ensslen, M; Gruber-Sedlmayr, U; Plecko, B; Brunner-Krainz, M; Schimmel, M; Schubert-Bast, S; Neirich, U; Philippi, H; Kurleman, G; Tardieu, M; Wohlrab, G; Borggraefe, I; Rostásy, K.
Epileptic phenotypes, electroclinical features and clinical characteristics in 17 children with anti-NMDAR encephalitis.
Eur J Paediatr Neurol. 2017; 21(3):457-464
Doi: 10.1016/j.ejpn.2016.11.016
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Brunner-Krainz Michaela
- Gruber-Sedlmayr Ursula
- Plecko Barbara
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- Abstract:
- Anti-N-methyl d-aspartate receptor (NMDAR) encephalitis is a rare disorder characterized by seizures, neuropsychiatric symptoms, dyskinesia and autonomic instability. Aim of the present study was to evaluate the seizure phenotypes and electroencephalogram (EEG) features in children with anti-NMDAR encephalitis. Seizure types, electroclinical features and clinical characteristics of 17 children with anti-NMDAR encephalitis were analysed in a retrospective case series from nine centres in Europe. Nearly half (8/17) of the children presented with psychiatric symptoms, whereas in 4/17 patients seizures were the first symptom and in 5/17 both symptoms occurred at the same time. During the following course seizures were reported in 16/17 children. The first EEG detected generalized slowing in 11/17 patients, focal slowing in 3/17 and normal background activity in only 3/17 children. The extreme delta brush (EDB) pattern was detected in 9/17 (53%) patients. In addition to psychiatric symptoms, children with anti-NMDAR encephalitis often show generalized slowing in EEG with or without seizures at initial presentation. EDB is present in half of all children and is potentially a helpful tool for early detection of this immune-mediated disease. Copyright © 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis - complications
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnosis
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis - physiopathology
- Child -
- Child, Preschool -
- Delta Rhythm - physiology
- Early Diagnosis -
- Electroencephalography -
- Female -
- Humans -
- Male -
- Phenotype -
- Retrospective Studies -
- Seizures - complications
- Seizures - diagnosis
- Seizures - physiopathology
- Find related publications in this database (Keywords)
- Anti-NMDAR encephalitis
- Epilepsy
- Children
- Focal seizures
- Generalized seizures
- Extreme
- Delta brush