Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pabinger, I; Fries, D; Schöchl, H; Streif, W; Toller, W.
Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis.
Wien Klin Wochenschr. 2017; 129(9-10):303-316
Doi: 10.1007/s00508-017-1194-y
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- Co-Autor*innen der Med Uni Graz
- Toller Wolfgang
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- Abstract:
- Uncontrolled massive bleeding with subsequent derangement of the coagulation system is a major challenge in the management of both surgical and seriously injured patients. Under physiological conditions activators and inhibitors of coagulation regulate the sensitive balance between clot formation and fibrinolysis. In some cases, excessive and diffuse bleeding is caused by systemic activation of fibrinolysis, i. e. hyperfibrinolysis (HF). Uncontrolled HF is associated with a high mortality. Polytrauma patients and those undergoing surgical procedures involving organs rich in plasminogen proactivators (e. g. liver, kidney, pancreas, uterus and prostate gland) are at a high risk for HF. Antifibrinolytics, such as tranexamic acid (TXA) are used for prophylaxis and treatment of bleeding caused by a local or generalized HF as well as other hemorrhagic conditions. TXA is a synthetic lysine analogue that has been available in Austria since 1966. TXA is of utmost importance in the prevention and treatment of traumatic and perioperative bleeding due to the resulting reduction in perioperative blood loss and blood transfusion requirements. The following article presents the different fields of application of TXA with particular respect to indications and dosages, based on a literature search and on current guidelines.
- Find related publications in this database (using NLM MeSH Indexing)
- Antifibrinolytic Agents - administration & dosage
- Blood Coagulation - drug effects
- Blood Coagulation Disorders - drug therapy
- Dose-Response Relationship, Drug -
- Fibrinolysis - drug effects
- Hematology - standards
- Hemorrhage - prevention & control
- Humans -
- Practice Guidelines as Topic -
- Tranexamic Acid - administration & dosage
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Trauma
- Surgery
- Bleeding
- Hyperfibrinolysis
- Tranexamic acid