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Martínez Vera, NP; Höller, J; Widek, T; Neumayer, B; Ehammer, T; Urschler, M.
Forensic age estimation by morphometric analysis of the manubrium from 3D MR images.
Forensic Sci Int. 2017; 277(7):21-29 Doi: 10.1016/j.forsciint.2017.05.005
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Leading authors Med Uni Graz: Martinez Vera Naira Pilar; Urschler Martin
Co-authors Med Uni Graz: Ehammer Thomas; Neumayer Bernhard; Widek Thomas
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Abstract:: Forensic age estimation research based on skeletal structures focuses on patterns of growth and development using different bones. In this work, our aim was to study growth-related evolution of the manubrium in living adolescents and young adults using magnetic resonance imaging (MRI), which is an image acquisition modality that does not involve ionizing radiation. In a first step, individual manubrium and subject features were correlated with age, which confirmed a statistically significant change of manubrium volume (M_vol:p<0.01, R²¯=0.50) and surface area (M_sur:p<0.01, R²¯=0.53) for the studied age range. Additionally, shapes of the manubria were for the first time investigated using principal component analysis. The decomposition of the data in principal components allowed to analyse the contribution of each component to total shape variation. With 13 principal components, ∼96% of shape variation could be described (M_shp:p<0.01, R²¯=0.60). Multiple linear regression analysis modelled the relationship between the statistically best correlated variables and age. Models including manubrium shape, volume or surface area divided by the height of the subject (Y∼M_shpM_sur/S_h:p<0.01, R²¯=0.71; Y∼M_shpM_vol/S_h:p<0.01, R²¯=0.72) presented a standard error of estimate of two years. In order to estimate the accuracy of these two manubrium-based age estimation models, cross validation experiments predicting age on held-out test sets were performed. Median absolute difference of predicted and known chronological age was 1.18 years for the best performing model (Y∼M_shpM_sur/S_h:p<0.01, R_p²=0.67). In conclusion, despite limitations in determining legal majority age, manubrium morphometry analysis presented statistically significant results for skeletal age estimation, which indicates that this bone structure may be considered as a new candidate in multi-factorial MRI-based age estimation. Copyright © 2017 Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Age Determination by Skeleton - methods; Forensic Anthropology -; Humans -; Imaging, Three-Dimensional -; Linear Models -; Magnetic Resonance Imaging -; Male -; Manubrium - diagnostic imaging; Manubrium - growth & development; Principal Component Analysis -; Retrospective Studies -; Young Adult -
Find related publications in this database (Keywords): Forensic age estimation; MRI; Manubrium; Morphometry; Principal component analysis