Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kieseier, BC; Seifert, T; Hartung, HP.
Matrix metalloproteinases. Potential targets for new treatments in inflammatory demyelinating diseases of the nervous system
NERVENARZT 1999 70: 509-516.
Doi: 10.1007/s001150050473
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Seifert-Held Thomas
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- Abstract:
- Inflammatory demyelinating diseases of the nervous system, such as multiple sclerosis or the Guillain-Barré syndrome represent severely disabling disorders, often seen by the neurologist, with still only limited means for therapeutical intervention. The underlying pathomechanisms remain in large part elusive, however mounting evidence suggests that enzymes of the family of matrix metalloproteinases are of relevance in the pathogenesis of these disorders. Experimental in vivo data as well as results from other medical fields emphasize that the selective inhibition of these proteases could be a promising therapeutical approach. The following review summarizes the role of matrix metalloproteinases in inflammatory demyelinating diseases of the central as well as peripheral nervous system and discusses the therapeutical application of synthetic inhibitors in these disorders.
- Find related publications in this database (using NLM MeSH Indexing)
- Autoimmune Diseases - physiopathology
- Cytokines - immunology
- Demyelinating Diseases - physiopathology
- Encephalomyelitis, Autoimmune, Experimental - physiopathology
- English Abstract - physiopathology
- Female - physiopathology
- Humans - physiopathology
- Hypersensitivity, Delayed - enzymology
- In Vitro - enzymology
- Male - enzymology
- Metalloendopeptidases - antagonists and inhibitors
- Multiple Sclerosis - physiopathology
- Neuritis, Autoimmune, Experimental - physiopathology
- Polyradiculoneuropathy - physiopathology
- Find related publications in this database (Keywords)
- Matrix Metalloproteinases
- Experimental Autoimmune Encephalomyelitis Multiple Sclerosis
- Experimental Autoimmune Neuritis
- Guillain-Barre Syndrome