Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Worel, N; Knobler, R; Greinix, HT.
Extracorporeal Photopheresis
TRANSFUSIONSMEDIZIN. 2016; 6(3): 115-122.
Doi: 10.1055/s-0042-110175
Web of Science
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Extracorporeal photopheresis (ECP) combines a leukapheresis procedure with UVA irradiation where nucleated cells such as lymphocytes and monocytes undergo extracorporeal UVA irradiation after a photosensitizer (8-Methoxypsoralen) has been added. ECP can be performed using different technical devices. The closed (inline) system consists of an apheresis device with an incorporated UVA source. Cells are collected and irradiated without being discontinued from the patient. In contrast, open (offline) systems use a conventional blood cell separator for mononuclear cell collection and a separate UVA source for irradiation. The therapeutic effect of ECP is based on a modulation of the cellular immune system leading to a reduction in T-cell activity. ECP is an integral part in the treatment of cutaneous T-cell lymphoma, acute and chronic graft-versus- host disease after allogeneic stem cell transplantation, and rejection episodes after heart and lung transplantation. Due to recent findings in the mechanism of action on the immune system, indications for ECP have been expanded to treat a range of additional diseases such as early systemic sclerosis (cutaneous component). ECP is a safe and effective treatment modality and associated with few side effects.
- Find related publications in this database (Keywords)
- mechanism of action of extracorporeal photopheresis
- cutaneous T-cell lymphoma
- graft-versus-host disease
- rejection after solid organ transplantation
- systemic sclerosis