Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Strenger, V; Farowski, F; Müller, C; Hofer, N; Dornbusch, HJ; Sperl, D; Lackner, H; Benesch, M; Urban, C.
Low penetration of caspofungin into cerebrospinal fluid following intravenous administration of standard doses.
Int J Antimicrob Agents. 2017; 50(2):272-275
Doi: 10.1016/j.ijantimicag.2017.02.024
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Strenger Volker
- Co-authors Med Uni Graz
- Benesch Martin
- Dornbusch Hans Jürgen
- Hofer Nora
- Lackner Herwig
- Sperl Daniela Ingrid
- Urban Ernst-Christian
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- Abstract:
- The kinetics of caspofungin (CAS) in cerebrospinal fluid (CSF) following intravenous (i.v.) administration has been studied exclusively in animal models. Human data are missing so far. In this study, 13 CSF samples were obtained at different time points following i.v. infusion of CAS in ten paediatric haemato-/oncological patients (age range 1.0-14.2 years, median 8.6 years) without signs of central nervous system (CNS) infection (n = 10 samples) or with infectious meningitis (n = 3 samples). Serum samples were obtained concurrently. Liquid chromatography-tandem mass spectrometry was used for CAS quantification. Whilst CAS serum levels were in the expected range, varying between 0.6 and 20.3 µg/mL (median 7.0 µg/mL), 11 of 13 CSF levels were below the limit of detection of 0.084 µg/mL at 3.0-48.0 h (median 23.3 h) following i.v. infusion. Only two (of three) levels in patients with bacterial meningitis were above the limit of detection (0.3 µg/mL and 0.09 µg/mL, respectively). These results indicate the low capacity of CAS to penetrate into the CNS even in inflamed meninges. Monotherapy with standard doses of CAS appears not to be suitable for treatment of fungal CNS infections. Copyright © 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Intravenous -
- Adolescent -
- Antifungal Agents - administration & dosage
- Antifungal Agents - pharmacokinetics
- Caspofungin -
- Cerebrospinal Fluid - chemistry
- Child -
- Child, Preschool -
- Chromatography, Liquid -
- Echinocandins - administration & dosage
- Echinocandins - pharmacokinetics
- Female -
- Humans -
- Infant -
- Lipopeptides - administration & dosage
- Lipopeptides - pharmacokinetics
- Male -
- Prospective Studies -
- Serum - chemistry
- Tandem Mass Spectrometry -
- Time Factors -
- Find related publications in this database (Keywords)
- Echinocandin
- Caspofungin
- Blood-brain barrier
- Invasive fungal infection
- CNS infection