Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Steinerová, A; Racek, J; Stozický, F; Tatzber, F; Lapin, A.
Autoantibodies against oxidized LDL in the first phase of life. Low density lipoproteins.
Clin Chem Lab Med. 1999; 37(9):913-917
Doi: 10.1515/CCLM.1999.135
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Tatzber Franz
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- Abstract:
- The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p<0.001). Its concentration in newborns was even higher than in their mothers (p<0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.
- Find related publications in this database (using NLM MeSH Indexing)
- Autoantibodies - analysis
- Cholesterol - blood
- Female -
- Free Radicals -
- Humans -
- Infant, Newborn - blood
- Infant, Newborn - immunology
- Lipoproteins, LDL - immunology
- Male -
- Malondialdehyde - blood
- Oxidative Stress -
- Superoxide Dismutase - blood
- Find related publications in this database (Keywords)
- oxidative stress
- malondialdehyde
- newborns
- lipoperoxidation
- autoantibodies
- oxidized LDL