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SHR Neuro Cancer Cardio Lipid Metab Microb

Langner, C.
[Hereditary gastric and pancreatic cancer].
Pathologe. 2017; 38(3):164-169 Doi: 10.1007/s00292-017-0297-6 [OPEN ACCESS]
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Leading authors Med Uni Graz: Langner Cord
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Abstract:: Most cases of gastric and pancreatic cancer are sporadic, but familial clustering can be observed in approximately 10% of cases. Hereditary gastric cancer accounts for a very low percentage of cases (1-3%) and two syndromes have been characterized: hereditary diffuse gastric cancer (HDGC) and gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS). Gastric and pancreatic cancer can develop in the setting of other hereditary cancer syndromes, such as hereditary breast and ovarian cancer syndrome (HBOC), Li-Fraumeni syndrome, Lynch syndrome, familial adenomatous polyposis (FAP), or various hamartomatous polyposis syndromes, including juvenile polyposis and Peutz-Jeghers syndrome. Patients with hereditary pancreatitis carry an increased risk of cancer (40-55%).
Find related publications in this database (Keywords): Hereditary cancer; Familial gastric cancer; Familial pancreatic cancer; Histopathology; Molecular biology