Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kerbert, AJ; Schaapman, JJ; van der Reijden, JJ; Amorós Navarro, À; McCormick, A; van Hoek, B; Arroyo, V; Ginès, P; Jalan, R; Vargas, V; Stauber, R; Verspaget, HW; Coenraad, MJ; CANONIC Study Investigators of the EASL-CLIF Consortium.
Short article: Impact of genetic variation in the vasopressin 1a receptor on the development of organ failure in patients admitted for acute decompensation of liver cirrhosis.
Eur J Gastroenterol Hepatol. 2017; 29(5):535-538
Doi: 10.1097/MEG.0000000000000834
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Stauber Rudolf
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- Abstract:
- Vasopressin receptor-mediated vasoconstriction is considered to be involved in the pathogenesis of organ failure in acute-on-chronic liver failure (ACLF). We studied the association between six single nucleotide polymorphisms (SNPs) of the vasopressin 1a receptor gene and the development of organ failure in 826 patients admitted for acute decompensation of liver cirrhosis (n=641) or ACLF (n=185). No associations were found for SNPs with the presence of circulatory or renal failure. A C>T mutation in SNP rs7308855 and a T>A mutation in SNP rs7298346 showed an association with the presence of coagulation failure in the entire population (n=61, P=0.024 and 0.060, respectively) and in the subgroup of patients with ACLF (n=44, P=0.081 and 0.056, respectively). Genetic variation in the vasopressin 1a receptor was found not to be associated with circulatory or renal failure, but with the presence of coagulation failure in patients with acute decompensation of liver cirrhosis and ACLF.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute-On-Chronic Liver Failure - complications
- Acute-On-Chronic Liver Failure - genetics
- Adult -
- Aged -
- Female -
- Gene Frequency -
- Genetic Variation -
- Genotyping Techniques -
- Humans -
- Liver Cirrhosis - complications
- Liver Cirrhosis - genetics
- Male -
- Middle Aged -
- Multiple Organ Failure - etiology
- Multiple Organ Failure - genetics
- Polymorphism, Single Nucleotide -
- Prospective Studies -
- Receptors, Vasopressin - genetics
- Find related publications in this database (Keywords)
- acute-on-chronic liver failure
- arginine vasopressin 1a receptor
- cirrhosis
- single nucleotide polymorphisms