Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ropele, S; Langkammer, C.
Iron quantification with susceptibility.
NMR Biomed. 2017; 30(4):
Doi: 10.1002/nbm.3534
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Ropele Stefan
- Co-Autor*innen der Med Uni Graz
- Langkammer Christian
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- Abstract:
- Iron is an essential trace element involved in a variety of biological mechanisms in the human body. Disturbances of iron homeostasis have been observed in several inflammatory and degenerative diseases, which have raised strong interest in non-invasive iron mapping techniques. Numerous MRI techniques have been proposed so far, mostly based on the field changes induced by the magnetic properties of iron. Each of these approaches has a specific sensitivity for iron and its microstructural environment. Quantitative susceptibility mapping is the latest development and provides a direct measure of bulk susceptibility. However, field changes induced by iron are not always directly related to the concentration of iron, but rather reflect the structure of iron compounds and its cellular distribution. This review provides an overview of the most relevant iron compounds in the human body, their magnetic properties and their cellular distribution. In addition, MRI methods based on direct or indirect susceptibility changes are presented and discussed with respect to technical aspects and clinical applicability. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biomarkers - analysis
- Biomarkers - chemistry
- Brain - anatomy & histology
- Brain Chemistry -
- Humans -
- Image Interpretation, Computer-Assisted - methods
- Iron - analysis
- Iron - chemistry
- Magnetic Resonance Spectroscopy - methods
- Molecular Imaging - methods
- Reproducibility of Results -
- Sensitivity and Specificity -
- Tissue Distribution -
- Find related publications in this database (Keywords)
- Iron
- Cellular distribution
- Ferritin
- Quantitative susceptibility mapping