Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tetyczka, C; Griesbacher, M; Absenger-Novak, M; Fröhlich, E; Roblegg, E.
Development of nanostructured lipid carriers for intraoral delivery of Domperidone.
Int J Pharm. 2017; 526(1-2):188-198
Doi: 10.1016/j.ijpharm.2017.04.076
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Absenger-Novak Markus
- Fröhlich Eleonore
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- Abstract:
- The oral cavity displays one potentially attractive route that is not associated with gastric transit and hepatic first pass metabolism. However, poorly soluble active candidates require a drug delivery system to facilitate their transport through oral biological membranes. To this end, nanostructured lipid carriers (NLC) were loaded with Domperidone and produced with high pressure homogenization. NLC were characterized regarding particle size, particle size distribution, zeta potential, entrapment efficiency and crystallinity. Moreover, permeability studies through the buccal mucosa were performed using in-vitro and ex-vivo models. Palmitic acid (solid lipid) and oleic acid (liquid lipid) in the ratio 9:1 were able to dissolve the highest amount of Domperidone. Particle diameters of about 280nm and monomodal size distribution were obtained. A zeta potential higher than -30mV was observed over a period of 28days indicating good physical stability. NLC dispersed in saliva did not agglomerate and were actively internalized by buccal TR 146 cells without causing adverse side effects. Ex-vivo studies confirmed that Domperidone permeated the entire tissue. This leads to the conclusion that NLC are appropriate carrier systems that facilitate the transport of poorly soluble drugs across buccal and sublingual tissue. Copyright © 2017 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Line, Tumor -
- Domperidone - administration & dosage
- Drug Carriers - chemistry
- Humans -
- In Vitro Techniques -
- Lipids - chemistry
- Mouth Mucosa -
- Nanostructures - chemistry
- Particle Size -
- Swine -
- Find related publications in this database (Keywords)
- Nanostructured lipid carriers NLC
- Domperidone
- Buccal mucosa
- Ex-vivo study
- In-vitro TR 146 cells