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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Friedmacher, F; Kroneis, B; Huber-Zeyringer, A; Schober, P; Till, H; Sauer, H; Höllwarth, ME.
Postoperative Complications and Functional Outcome after Esophageal Atresia Repair: Results from Longitudinal Single-Center Follow-Up.
J Gastrointest Surg. 2017; 21(6):927-935
Doi: 10.1007/s11605-017-3423-0
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- Leading authors Med Uni Graz
- Friedmacher Florian
- Co-authors Med Uni Graz
- Höllwarth Michael
- Huber-Zeyringer Andrea
- Till Holger
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- Abstract:
- Esophageal atresia (EA) and tracheoesophageal fistula (TEF) represent major therapeutic challenges, frequently associated with serious morbidities following surgical repair. The aim of this longitudinal study was to assess temporal changes in morbidity and mortality of patients with EA/TEF treated in a tertiary-level center, focusing on postoperative complications and their impact on long-term gastroesophageal function. One hundred nine consecutive patients with EA/TEF born between 1975 and 2011 were followed for a median of 9.6 years (range, 3-27 years). Comparative statistics were used to evaluate temporal changes between an early (1975-1989) and late (1990-2011) study period. Gross types of EA were A (n = 6), B (n = 5), C (n = 89), D (n = 7), and E (n = 2). Seventy (64.2%) patients had coexisting anomalies, 13 (11.9%) of whom died before EA correction was completed. In the remaining 96 infants, surgical repair was primary (n = 66) or delayed (n = 25) anastomosis, closure of TEF in EA type E (n = 2), and esophageal replacement with colon interposition (n=2) or gastric transposition (n=1). Long-gap EA was diagnosed in 23 (24.0%) cases. Postoperative mortality was 4/96 (4.2%). Overall survival increased significantly between the two study periods (42/55 vs. 50/54; P = 0.03). Sixty-nine (71.9%) patients presented postoperatively with anastomotic strictures requiring a median of 3 (range, 1-15) dilatations. Revisional surgery was required for anastomotic leakage (n = 5), recurrent TEF with (n = 1) or without (n=9) anastomotic stricture, undetected proximal TEF (n = 4), and refractory anastomotic strictures with (n = 1) or without (n = 2) fistula. Normal dietary intake was achieved in 89 (96.7%) patients, while 3 (3.3%) remained dependent on gastrostomy feedings. Manometry showed esophageal dysmotility in 78 (84.8%) infants at 1 year of age, increasing to 100% at 10-year follow-up. Fifty-six (60.9%) patients suffered from dysphagia with need for endoscopic foreign body removal in 12 (13.0%) cases. Anti-reflux medication was required in 43 (46.7%) children and 30 (32.6%) underwent fundoplication. The rate of gastroesophageal reflux increased significantly between the two study periods (29/42 vs. 44/50; P = 0.04). Twenty-two (23.9%) cases of endoscopic esophagitis and one Barrett's esophagus were identified. Postoperative complications after EA/TEF repair are common and should be expertly managed to reduce the risk of long-term morbidity. Regular multidisciplinary surveillance with transitional care into adulthood is recommended in all patients with EA/TEF.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Esophageal Atresia - mortality
- Esophageal Atresia - physiopathology
- Esophageal Atresia - surgery
- Female -
- Follow-Up Studies -
- Humans -
- Infant -
- Infant, Newborn -
- Male -
- Postoperative Complications - diagnosis
- Postoperative Complications - epidemiology
- Postoperative Complications - therapy
- Recovery of Function -
- Time Factors -
- Tracheoesophageal Fistula - mortality
- Tracheoesophageal Fistula - physiopathology
- Tracheoesophageal Fistula - surgery
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- Esophageal atresia
- Tracheoesophageal fistula
- Complications
- Follow-up
- Outcome
- Gastroesophageal function