Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wurzer, P; Cole, MR; Clayton, RP; Hundeshagen, G; Nunez Lopez, O; Cambiaso-Daniel, J; Winter, R; Branski, LK; Hawkins, HK; Finnerty, CC; Herndon, DN; Lee, JO.
Herpesviradae infections in severely burned children.
Burns. 2017; 43(5):987-992
Doi: 10.1016/j.burns.2017.01.032
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- Führende Autor*innen der Med Uni Graz
- Wurzer Paul
- Co-Autor*innen der Med Uni Graz
- Branski Ludwik
- Cambiaso Daniel Janos
- Winter Raimund
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- Abstract:
- Burn-related immunosuppression can promote human herpesviridae infections. However, the effect of these infections on morbidity and mortality after pediatric burn injuries is unclear. We retrospectively analyzed pediatric patients with burns ≥10% of the total body surface area (TBSA) who were admitted between 2010 and 2015. On clinical suspicion of a viral infection, antiviral therapy was initiated. Viral infection was confirmed via Tzanck smear, viral culture, and/or PCR. Study endpoints were mortality, days of antiviral agent administration, type of viral test used, type of viral infection, and length of hospitalization. Of the 613 patients were analyzed, 28 presented with clinically diagnosed viral infections. The use of Tzanck smears decreased over the past 5 years, whereas PCR and viral cultures have become standard. Patients with viral infections had significantly larger burns (53±15% vs. 38±18%, p<0.001); however, length of stay per TBSA burn was comparable (0.5±0.4 vs. 0.6±0.2, p=0.211). The most commonly detected herpesviridae was herpes simplex virus 1. Two patients died due to sepsis, which was accompanied by HSV infection. The mortality rate among all patients (2.7%) was comparable to that in the infected group (7.1%, p=0.898). Acyclovir was given systemically for 9±8days (N=76) and/or topically for 9±9days for HSV (N=39, combination of both N=33). Ganciclovir was prescribed in three cases for CMV. Viral infections occur more commonly in patients suffering from larger burns, and HSV infections can contribute to mortality. Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antiviral Agents - therapeutic use
- Burns - mortality
- Burns - therapy
- Burns - virology
- Child -
- Child, Preschool -
- Female -
- Herpesviridae - isolation & purification
- Herpesviridae Infections - diagnosis
- Herpesviridae Infections - drug therapy
- Herpesviridae Infections - etiology
- Humans -
- Infant -
- Male -
- Polymerase Chain Reaction -
- Retrospective Studies -
- Risk Factors -
- Sepsis - virology
- Virology - methods
- Wound Infection - diagnosis
- Wound Infection - drug therapy
- Wound Infection - virology
- Find related publications in this database (Keywords)
- Viral cultures
- Cytomegalovirus
- Tzanck smear
- Polymerase chain reaction
- Acyclovir