Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Perakis, S; Speicher, MR.
Emerging concepts in liquid biopsies.
BMC Med. 2017; 15(1):75-75
Doi: 10.1186/s12916-017-0840-6
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- Führende Autor*innen der Med Uni Graz
- Hasenleithner Samantha
- Speicher Michael
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- Abstract:
- Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tumor cells, circulating tumor DNA, and tumor-derived exosomes, often referred to as "liquid biopsies", may enable tumor genome characterization by minimally invasive means. Indeed, multiple studies have described how molecular information about parent tumors can be extracted from these components. Here, we briefly summarize current technologies and then elaborate on emerging novel concepts that may further propel the field. We address normal and detectable mutation levels in the context of our current knowledge regarding the gradual accumulation of mutations during aging and in light of technological limitations. Finally, we discuss whether liquid biopsies are ready to be used in routine clinical practice.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Biopsy - methods
- DNA, Neoplasm - blood
- DNA, Neoplasm - genetics
- Humans -
- Neoplastic Cells, Circulating - pathology
- Precision Medicine - methods
- Find related publications in this database (Keywords)
- Cell-free DNA
- Circulating tumor DNA
- Circulating tumor cells
- Liquid biopsy
- Disease monitoring
- Precision medicine