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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Reintam Blaser, A; Starkopf, J; Alhazzani, W; Berger, MM; Casaer, MP; Deane, AM; Fruhwald, S; Hiesmayr, M; Ichai, C; Jakob, SM; Loudet, CI; Malbrain, ML; Montejo González, JC; Paugam-Burtz, C; Poeze, M; Preiser, JC; Singer, P; van Zanten, AR; De Waele, J; Wendon, J; Wernerman, J; Whitehouse, T; Wilmer, A; Oudemans-van Straaten, HM; ESICM Working Group on Gastrointestinal Function.
Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines.
Intensive Care Med. 2017; 43(3):380-398
Doi: 10.1007/s00134-016-4665-0
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- Co-authors Med Uni Graz
- Fruhwald Sonja
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- Abstract:
- To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. We aimed to compare EEN vs. early parenteral nutrition (PN) and vs. delayed EN. We defined "early" EN as EN started within 48 h independent of type or amount. We listed, a priori, conditions in which EN is often delayed, and performed systematic reviews in 24 such subtopics. If sufficient evidence was available, we performed meta-analyses; if not, we qualitatively summarized the evidence and based our recommendations on expert opinion. We used the GRADE approach for guideline development. The final recommendations were compiled via Delphi rounds. We formulated 17 recommendations favouring initiation of EEN and seven recommendations favouring delaying EN. We performed five meta-analyses: in unselected critically ill patients, and specifically in traumatic brain injury, severe acute pancreatitis, gastrointestinal (GI) surgery and abdominal trauma. EEN reduced infectious complications in unselected critically ill patients, in patients with severe acute pancreatitis, and after GI surgery. We did not detect any evidence of superiority for early PN or delayed EN over EEN. All recommendations are weak because of the low quality of evidence, with several based only on expert opinion. We suggest using EEN in the majority of critically ill under certain precautions. In the absence of evidence, we suggest delaying EN in critically ill patients with uncontrolled shock, uncontrolled hypoxaemia and acidosis, uncontrolled upper GI bleeding, gastric aspirate >500 ml/6 h, bowel ischaemia, bowel obstruction, abdominal compartment syndrome, and high-output fistula without distal feeding access.
- Find related publications in this database (using NLM MeSH Indexing)
- Cohort Studies -
- Critical Illness - therapy
- Enteral Nutrition - methods
- Enteral Nutrition - standards
- Evidence-Based Medicine -
- Humans -
- Randomized Controlled Trials as Topic -
- Time Factors -
- Find related publications in this database (Keywords)
- Abdominal problems
- Parenteral nutrition
- Contraindications
- GI symptoms
- Early enteral nutrition
- Delay of enteral nutrition