Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Haymerle, G; Kadletz, L; Wiebringhaus, R; Golabi, B; Mildner, M; Thurnher, D; Heiduschka, G.
ELMO3 predicts poor outcome in T1 laryngeal cancer.
Clin Otolaryngol. 2017; 42(6):1181-1186
Doi: 10.1111/coa.12845
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Thurnher Dietmar
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- Abstract:
- Despite the excellent overall survival of 92%-97% in early glottic cancer, recurrence rates of 13%-20% have not improved in the last decades. The engulfment and cell motility protein 3 (ELMO3) have been described as prognostic marker in patients with lung cancer. The aim of this study was to investigate the expression of ELMO3 in early laryngeal cancer patients treated with TLM and to evaluate its prognostic significance on clinical outcome. Forty-eight patients with glottic carcinoma (T1N0M0) that underwent primary treatment with TLM between 1994 and 2012 were analysed. ELMO3 expression of the tumour was assessed using immunohistochemistry and correlated with clinical data. Overall survival, disease-specific survival (DSS) and disease-free survival (DFS) rates RESULTS: Positive ELMO3 expression was found in 23% of the patients and was correlated with poor DSS and DFS (P<.05). This is the first study to show a prognostic effect of positive ELMO3 expression in early glottic carcinoma patients. © 2017 John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptor Proteins, Signal Transducing - metabolism
- Adult -
- Aged -
- Carcinoma, Squamous Cell - metabolism
- Carcinoma, Squamous Cell - mortality
- Carcinoma, Squamous Cell - surgery
- Cytoskeletal Proteins - metabolism
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- Female -
- Glottis -
- Humans -
- Laryngeal Neoplasms - metabolism
- Laryngeal Neoplasms - mortality
- Laryngeal Neoplasms - surgery
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- Find related publications in this database (Keywords)
- ELMO3
- immunohistochemistry
- laryngeal cancer
- laryngeal squamous cell carcinoma
- outcome