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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ruan, Y; Thabit, H; Leelarathna, L; Hartnell, S; Wilinska, ME; Tauschmann, M; Dellweg, S; Benesch, C; Mader, JK; Holzer, M; Kojzar, H; Evans, ML; Pieber, TR; Arnolds, S; Hovorka, R; AP@home consortium.
Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes.
Diabetes Obes Metab. 2017; 19(10):1485-1489
Doi: 10.1111/dom.12956
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- Co-authors Med Uni Graz
- Holzer Manuel
- Kojzar Harald
- Mader Julia
- Pieber Thomas
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- Abstract:
- We aimed to evaluate the relationship between insulin pharmacodynamics and glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy. We retrospectively analysed data from a multicentre randomized control trial involving 32 adults with type 1 diabetes receiving day-and-night closed-loop insulin delivery and sensor-augmented pump therapy over 12 weeks. We estimated time-to-peak insulin action (t max,IA ) and insulin sensitivity ( S I ) during both interventions, and correlated these with demographic factors and glycaemic outcomes. During both interventions, t max,IA was positively correlated with pre- and post-intervention HbA1c (r = 0.50-0.52, P < .01) and mean glucose (r = 0.45-0.62, P < .05), and inversely correlated with time sensor glucose, which was in target range 3.9 to 10 mmol/L (r = -0.64 to -0.47, P < .05). Increased body mass index was associated with higher t max,I and lower S I (both P < .05). During closed-loop insulin delivery, t max,IA was positively correlated with glucose variability ( P < .05). Faster insulin action is associated with improved glycaemic control during closed-loop insulin delivery and sensor-augmented pump therapy. © 2017 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biosensing Techniques - instrumentation
- Biosensing Techniques - methods
- Blood Glucose - analysis
- Blood Glucose Self-Monitoring - instrumentation
- Blood Glucose Self-Monitoring - methods
- Diabetes Mellitus, Type 1 - blood
- Diabetes Mellitus, Type 1 - drug therapy
- Female -
- Humans -
- Insulin - administration & dosage
- Insulin - pharmacology
- Insulin Infusion Systems -
- Male -
- Middle Aged -
- Retrospective Studies -
- Time Factors -
- Treatment Outcome -
- Young Adult -
- Find related publications in this database (Keywords)
- CSII
- glycaemic control
- insulin delivery
- insulin pump therapy
- pharmacodynamics
- type 1 diabetes