Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schneditz, D; Niemczyk, S; Sauseng, N; Bachler, I; Zierler, E; Lackner, HK; Hafner-Giessauf, H.
Osmotic and Hemodynamic Effects of Hypertonic Glucose During Hemodialysis.
ASAIO J. 2017; 63(6):824-831
Doi: 10.1097/MAT.0000000000000574
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schneditz Daniel
- Co-Autor*innen der Med Uni Graz
- Bachler Isolde
- Hafner-Giessauf Hildegard Elisabeth
- Lackner Helmut Karl
- Sauseng Notburga
- Zierler Edda
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- Abstract:
- It was the purpose to quantify the hemodynamic effects of a bolus of hypertonic glucose injected into the extracorporeal system in a group of stable and nondiabetic patients during hemodialysis (HD). Glucose and electrolytes were measured in frequent intervals. Arterial blood pressures and heart rates were continuously recorded by noninvasive vascular unloading technique. Beat-to-beat stroke volume, cardiac output, and total peripheral resistance were determined by Modelflow method. Relative blood volumes were continuously measured by ultrasonic and optical means. Eight patients were studied in two treatments. Although arterial pressures and heart rates remained stable, stroke volume and cardiac output transiently increased above (19.2 ± 12.3%) and total peripheral resistance dropped below baseline (18.2 ± 8.6%) by a comparable magnitude. Relative blood volume transiently increased above baseline at 100% (104.9 ± 1.0%). Glucose concentrations were significantly related to relative blood volumes (r = 0.86, p < 0.001). In spite of a substantial increase in blood volume, a bolus of hypertonic glucose does not increase arterial pressures in nondiabetic patients because of concomitant vasodilatation. The relative increase in blood volume quantified by noninvasive HD technology follows the course of glucose and could be used as a surrogate to characterize patients with regard to their glucose metabolism during HD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Blood Volume - drug effects
- Glucose Solution, Hypertonic - pharmacology
- Hemodynamics - drug effects
- Humans -
- Middle Aged -
- Osmosis - drug effects
- Renal Dialysis - methods
- Find related publications in this database (Keywords)
- hemodialysis
- blood volume
- hemodynamics
- glucose
- vascular refilling