Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kosol, S; Schrank, E; Krajačić, MB; Wagner, GE; Meyer, NH; Göbl, C; Rechberger, GN; Zangger, K; Novak, P.
Probing the interactions of macrolide antibiotics with membrane-mimetics by NMR spectroscopy.
J Med Chem. 2012; 55(11): 5632-5636.
Doi: 10.1021/jm300647f
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- Co-authors Med Uni Graz
- Wagner-Lichtenegger Gabriel
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- Abstract:
- Interactions of macrolide antibiotics with biological membranes contribute to their bioavailability but are also involved in the formation of phospholipidosis, which is caused by the inhibition of phospholipase A(1) activity. We determined the interaction strength and localization of macrolide antibiotics with membrane-mimetics. Macrolides bind to membrane-mimetics with the positively charged amino groups being close to the micelle surface and thereby protect the lipids from being degraded by phospholipase A(1) rather than inhibiting the enzyme.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - chemistry
- Azithromycin - chemistry
- Diffusion -
- Macrolides - chemistry
- Magnetic Resonance Spectroscopy -
- Membranes, Artificial -
- Micelles -
- Models, Molecular -
- Molecular Mimicry -
- Phosphatidylserines - chemistry
- Phospholipases A1 - chemistry
- Phosphorylcholine - analogs & derivatives
- Phosphorylcholine - chemistry
- Sodium Dodecyl Sulfate - chemistry
- Structure-Activity Relationship -