Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wurm, P; Spindelboeck, W; Krause, R; Plank, J; Fuchs, G; Bashir, M; Petritsch, W; Halwachs, B; Langner, C; Högenauer, C; Gorkiewicz, G.
Antibiotic-Associated Apoptotic Enterocolitis in the Absence of a Defined Pathogen: The Role of Intestinal Microbiota Depletion.
Crit Care Med. 2017; 45(6):e600-e606
Doi: 10.1097/CCM.0000000000002310
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Gorkiewicz Gregor
- Wurm Philipp
- Co-Autor*innen der Med Uni Graz
- Bashir Mina
- Fuchs Gottfried
- Halwachs-Wenzl Bettina
- Hoegenauer Christoph
- Krause Robert
- Langner Cord
- Petritsch Wolfgang
- Spindelböck Walter Johann
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- Abstract:
- OBJECTIVE: Antibiotic therapy is a major risk factor for the development of diarrhea and colitis with varying severity. Often the origin of antibiotic-associated gastrointestinal deterioration remains elusive and no specific infectious agents could be discerned. PATIENTS: We represent three cases of intractable high-volume diarrhea associated with combined antibiotic and steroid therapy in critically ill patients not fitting into established disease entities. Cases presented with severe apoptotic enterocolitis resembling acute intestinal graft-versus-host-disease. Microbiologic workup precluded known enteropathogens, but microbiota analysis revealed a severely depleted gut microbiota with concomitant opportunistic pathogen overgrowth. INTERVENTIONS: Fecal microbiota transplantation, performed in one patient, was associated with correction of dysbiosis, rapid clinical improvement, and healing of enterocolitis. CONCLUSIONS: Our series represents a severe form of antibiotic-associated colitis in critically ill patients signified by microbiota depletion, and reestablishment of a physiologic gastrointestinal microbiota might be beneficial for this condition.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Adult - administration & dosage
- Anti-Bacterial Agents - adverse effects
- Enterocolitis - chemically induced, microbiology, therapy
- Fecal Microbiota Transplantation - methods
- Female - administration & dosage
- Gastrointestinal Microbiome - drug effects
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Find related publications in this database (Keywords)
- antibiotic-associated colitis
- epithelial apoptosis
- fecal microbiota transplantation
- high-volume diarrhea
- microbiota depletion