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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Donnerer, J; Liebmann, I.
Effects of Allyl Isothiocyanate, Acetaminophen, and Dipyrone in the Guinea-Pig Ileum.
PHARMACOLOGY. 2017; 99(1-2): 79-83.
Doi: 10.1159/000452164
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Donnerer Josef
- Co-authors Med Uni Graz
- Liebmann Ingrid
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- Abstract:
- Allyl isothiocyanate (AITC, mustard oil, 50-200 µmol/l), depending on specific dosages, inhibited the cholinergic twitch response in the longitudinal muscle-myenteric plexus (LMMP) strip of the guinea-pig ileum. AITC also induced short-lasting contractile responses, and decreases of the basal tone of the LMMP strip at low concentrations and increases at high concentrations. Hexamethonium, a blocker of nicotinic ganglionic transmission, was able to prevent the AITC-evoked inhibitory effect, an effect that was also observed with the opioid antagonist naloxone. The P2 purinoceptor antagonist pyridoxalphosphate-6-azophenyl-2'-4'-disulphonic acid and guanethidine had no significant influence on the inhibitory effect of AITC. Since AITC also reduced the electrical stimulation-induced myogenic smooth muscle contractions in the LMMP preparation, its contractile and relaxant actions can be regarded as neurogenic and myogenic in nature. The analgesics, acetaminophen (paracetamol, 100-500 µmol/l) and dipyrone (metamizole, 100-500 µmol/l), reduced both the cholinergic twitch and the myogenic contractions in the LMMP strip to the same extent; therefore, their action in the intestinal smooth muscle can be regarded as myogenic spasmolytic in nature. © 2016 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetaminophen - pharmacology
- Analgesics - pharmacology
- Animals -
- Dipyrone - pharmacology
- Dose-Response Relationship, Drug -
- Guinea Pigs -
- Ileum - drug effects
- Ileum - physiology
- Isothiocyanates - pharmacology
- Male -
- Muscle Contraction - drug effects
- Muscle Contraction - physiology
- Narcotic Antagonists - pharmacology
- Organ Culture Techniques -
- Find related publications in this database (Keywords)
- Intestinal smooth muscle
- Allyl isothiocyanate
- Paracetamol
- Metamizole
- Myogenic spasmolytic