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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Zirngast, PT; Aberer, F; Pieber, TR; Amrein, K; Schwetz, V.
Osteoporosis and Hypogonadism in Hemochromatosis
J MINERAL. 2016; 23(2): 48-50.
[OPEN ACCESS]
Web of Science
- Leading authors Med Uni Graz
- Amrein Karin
- Co-authors Med Uni Graz
- Aberer Felix
- Pieber Thomas
- Theiler-Schwetz Verena
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- Abstract:
- We present the case of a 46-year-old male patient with multiple low-trauma vertebral fractures who was subsequently diagnosed with osteoporosis and hypogonadotropic hypogonadism. Thirteen years earlier, the patient had been diagnosed with hereditary hemochromatosis. Although phlebotomy was regularly performed every three weeks, the patient had developed typical complications of iron overload. Hereditary hemochromatosis can lead to iron deposition in endocrine organs such as the pancreas, the pituitary and the adrenal glands. Hypogonadotropic hypogonadism is the most common non-diabetic endocrinopathy and may lead to osteoporosis. Additionally, iron itself has a direct negative effect on osteoblasts. Adequate treatment of hemochromatosis may lead to reversibility of hypogonadism and to an improvement of bone mineral density. Reversibility might, however, depend on age of disease onset, and so hypogonadism and osteoporosis can often persist. Current guidelines on hemochromatosis do not provide clear recommendations on diagnosis and management of hypogonadism and osteoporosis.
- Find related publications in this database (Keywords)
- hemochromatosis
- hypogonadism
- osteoporosis
- testosterone
- fractures