Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Holzer, LA.
Holzer LA
Die Bedeutung des subchondralen Knochens bei der Initiation und Progression der Arthrose
Journal für Mineralstoffwechsel. 2017; 24(1): 4-8.
[OPEN ACCESS]
Web of Science
- Führende Autor*innen der Med Uni Graz
- Holzer Lukas
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- Abstract:
- The presence of subchondral sclerosis in conventional X-rays is a classic sign of advanced stage osteoarthritis beside joint space narrowing, as well as the formation of osteophytes and subchondral bone cysts. The role of subchondral bone in the progression of osteoarthritis is discussed controversially. Cartilage and subchondral bone are seen as a functional unit. Both tissues are connected mechanically and biologically. Therefore the integrity of subchondral bone is of importance for a physiological joint function. Changes in one tissue will affect the integrity of the other and vice versa. Considering this perspective, the subchondral bone might pose a novel potential target for the treatment of osteoarthritis. A "disease-modifying osteoarthritis drug" (DMOAD) is a medication with the potential to reduce symptoms of a disease and in addition reduce its progression and improve function. Medications that are used for the treatment of osteoporosis such as anti-resorptive drugs, osteo-anabolic drugs or drugs with a dual mechanism are seen as potential pharmacologic interventions for the treatment of osteoarthritis. However, further clinical studies are required to close gaps of current scientific knowledge.
- Find related publications in this database (Keywords)
- osteoarthritis
- subchondral bone
- pathogenesis
- pharmacological treatment