Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weyerer, V; Schneckenpointner, R; Filbeck, T; Burger, M; Hofstaedter, F; Wild, PJ; Fine, SW; Humphrey, PA; Dehner, LP; Amin, MB; Rüschoff, J; Boltze, C; Tannapfel, A; Zwarthoff, E; Lopez-Beltran, A; Montironi, R; Langner, C; Stoehr, R; Hartmann, A; Giedl, J.
Immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years.
J Cancer. 2017; 8(3):323-331
Doi: 10.7150/jca.17482
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- Langner Cord
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- Abstract:
- Bladder tumours in early-onset patients are rare and seem to exhibit unique clinicopathological features. Only few studies have investigated somatic alterations in this specific age of onset group and evidence is accumulating of a distinct molecular behaviour of early-onset bladder tumours. We collected the largest cohort of early-onset tumours of patients 45 years old or younger and aimed to test genomic alterations typically found in bladder cancer. Tumours of 118 early-onset patients were compared with a consecutive group of 113 cases. Immunohistochemistry of TP53, CK20 and Ki-67 was carried out. Molecular analysis was conducted to test for loss of heterozygosity of chromosome 9 and 17, as well as TP53 and FGFR3 mutations. Fisher´s exact and chi-squared test were appropriately used. No differences in grade/stage characteristics were observed. Overexpressed TP53 was differentially distributed between the two groups. TP53 nuclear accumulation was significantly more frequent in early-onset papillomas, PUNLMPs and pTa low-grade tumours compared to the consecutive cohort (p=0.005). Moreover, chromosome 9 deletions (29.5% vs. 44.6%) and FGFR3 mutations (34.5% vs. 63.7%) were less often detected in early-onset patients (p=0.05 and p<0.0001). By comparing the largest cohort of early-onset bladder cancer patients with an unselected group, we demonstrated that the typical molecular features are not independent of age at diagnosis. Our study supports the hypothesis of a distinct biological behaviour in early-onset tumours.
- Find related publications in this database (Keywords)
- Early-onset
- Bladder cancer
- FGFR3
- TP53 positivity
- Mutation analysis.