Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kandolf Sekulovic, L; Peris, K; Hauschild, A; Stratigos, A; Grob, JJ; Nathan, P; Dummer, R; Forsea, AM; Hoeller, C; Gogas, H; Demidov, L; Lebbe, C; Blank, C; Olah, J; Bastholt, L; Herceg, D; Neyns, B; Vieira, R; Hansson, J; Rutkowski, P; Krajsova, I; Bylaite-Bucinskiene, M; Zalaudek, I; Maric-Brozic, J; Babovic, N; Banjin, M; Putnik, K; Weinlich, G; Todorovic, V; Kirov, K; Ocvirk, J; Zhukavets, A; Kukushkina, M; De La Cruz Merino, L; Ymeri, A; Risteski, M; Garbe, C.
More than 5000 patients with metastatic melanoma in Europe per year do not have access to recommended first-line innovative treatments.
Eur J Cancer. 2017; 75(4):313-322
Doi: 10.1016/j.ejca.2017.01.012
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Zalaudek Iris
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Despite the efficacy of innovative treatments for metastatic melanoma, their high costs has led to disparities in cancer care among different European countries. We analysed the availability of these innovative therapies in Europe and estimated the number of patients without access to first-line recommended treatment per current guidelines of professional entities such as the European Society for Medical Oncology (ESMO), the European Organisation for Research and Treatment of Cancer (EORTC), the European Association of Dermato-Oncology (EADO), and European Dermatology Forum (EDF). Web-based online survey was conducted in 30 European countries with questions about the treatment schedules from 1st May 2015 to 1st May 2016: number of metastatic melanoma patients, registration and reimbursement of innovative medicines (updated data, as of 1st October 2016), percentage of patients treated and availability of clinical studies and compassionate-use programmes. The recommended BRAF inhibitor (BRAFi) + MEK inhibitor (MEKi) combination was both registered and fully reimbursed in 9/30 (30%) countries, and in 13/30 (43%) (all from Eastern Europe) not reimbursed. First-line immunotherapy with anti-PD1 antibodies was registered and fully reimbursed in 14/30 (47%) countries, while in 13/30 (43%) (all from Eastern Europe) not reimbursed. It was estimated that in Europe 19,600 patients with metastatic melanoma are treated, and 5238 (27%) do not have access to recommended first-line therapy. Significant correlation was found between human development index (HDI, UNDP report 2015), (r = 0.662; p < 0.001), health expenditure per capita (r = 0.695; p < 0.001) and the Mackenbach score of health policy performance (r = 0.765; p < 0.001) with the percentage of patients treated with innovative medicines and a number of reimbursed medicines. Great discrepancy exists in metastatic melanoma treatment across Europe. It is crucial to increase the awareness of national and European policymakers, oncological societies, melanoma patients' associations and pharma industry. Copyright © 2017 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Acrylonitrile - analogs & derivatives
- Acrylonitrile - economics
- Acrylonitrile - supply & distribution
- Aniline Compounds - economics
- Aniline Compounds - supply & distribution
- Antibodies, Monoclonal, Humanized - economics
- Antibodies, Monoclonal, Humanized - therapeutic use
- Europe - epidemiology
- Female -
- Health Services Accessibility - economics
- Health Services Accessibility - statistics & numerical data
- Healthcare Disparities - economics
- Healthcare Disparities - statistics & numerical data
- Humans -
- Immunotherapy - economics
- Immunotherapy - statistics & numerical data
- Male -
- Melanoma - economics
- Melanoma - epidemiology
- Melanoma - therapy
- Programmed Cell Death 1 Receptor - antagonists & inhibitors
- Proto-Oncogene Proteins B-raf - antagonists & inhibitors
- Reimbursement Mechanisms - statistics & numerical data
- Skin Neoplasms - economics
- Skin Neoplasms - epidemiology
- Skin Neoplasms - therapy
- Therapies, Investigational - economics
- Therapies, Investigational - statistics & numerical data
- Find related publications in this database (Keywords)
- Access
- Innovative medicines
- Metastatic melanoma
- Treatment
- Immuno oncology
- Targeted therapy
- Health expenditure per capita
- Human development index