Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fahrner, M; Muik, M; Derler, I; Schindl, R; Fritsch, R; Frischauf, I; Romanin, C.
Mechanistic view on domains mediating STIM1-Orai coupling.
Immunol Rev. 2009; 231(1): 99-112.
Doi: 10.1111/j.1600-065X.2009.00815.x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Schindl Rainer
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- Abstract:
- Calcium (Ca2+) entry into non-excitable cells is mainly carried by store-operated channels, which serve essential functions ranging from regulation of transcription to cell growth. The best-characterized store-operated current, initially discovered in T lymphocytes and mast cells, is the Ca2+ release-activated Ca2+ (CRAC) current. The search for the molecular components of the CRAC channel has recently identified stromal interaction molecule 1 (STIM1) as the Ca2+ sensor in the endoplasmic reticulum (ER) and Orai1 as the CRAC channel pore. ER store depletion results in formation of STIM1 puncta that trigger Ca2+ influx via Orai1 channels. This review covers the role of domains within STIM1 and Orai and enlightens their function in the STIM1/Orai coupling process. Moreover, a molecular interpretation focuses on interactions between cytosolic portions of STIM1 and Orai together with a mechanistic view on the loss of function of the SCID (severe combined immunodeficiency)-linked Orai1 R91W mutant channel. The architecture of the selectivity filter of Orai channels is finally elucidated based on permeation properties of Orai pore mutants.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium - metabolism
- Calcium Channels - chemistry
- Calcium Channels - genetics
- Calcium Channels - metabolism
- Cytosol - metabolism
- Humans -
- Membrane Proteins - chemistry
- Membrane Proteins - genetics
- Membrane Proteins - metabolism
- Protein Binding -
- Find related publications in this database (Keywords)
- signal transduction
- signaling proteins
- immunodeficiency diseases
- mast cells
- T cells