Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Muik, M; Schindl, R; Fahrner, M; Romanin, C.
Ca(2+) release-activated Ca(2+) (CRAC) current, structure, and function.
Cell Mol Life Sci. 2012; 69(24): 4163-4176.
Doi: 10.1007/s00018-012-1072-8
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- Co-Autor*innen der Med Uni Graz
- Schindl Rainer
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- Abstract:
- Store-operated Ca(2+) entry describes the phenomenon that connects a depletion of internal Ca(2+) stores to an activation of plasma membrane-located Ca(2+) selective ion channels. Tremendous progress towards the underlying molecular mechanism came with the discovery of the two respective limiting components, STIM and Orai. STIM1 represents the ER-located Ca(2+) sensor and transmits the signal of store depletion to the plasma membrane. Here it couples to and activates Orai, the highly Ca(2+)-selective pore-forming subunit of Ca(2+) release-activated Ca(2+) channels. In this review, we focus on the molecular steps that these two proteins undergo from store-depletion to their coupling, the activation, and regulation of Ca(2+) currents.
- Find related publications in this database (using NLM MeSH Indexing)
- Calcium - chemistry
- Calcium - metabolism
- Calcium Channels - chemistry
- Calcium Channels - metabolism
- Calcium Channels - physiology
- Calcium Signaling - physiology
- Membrane Proteins - chemistry
- Membrane Proteins - metabolism
- Membrane Proteins - physiology
- Models, Biological -
- Neoplasm Proteins - chemistry
- Neoplasm Proteins - metabolism
- Neoplasm Proteins - physiology
- ORAI1 Protein -
- Protein Structure, Tertiary -
- Stromal Interaction Molecule 1 -
- Find related publications in this database (Keywords)
- STIM1
- Orai
- STIM1/Orai interaction
- Orai gating
- STIM1 structure