Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Derler, I; Schindl, R; Fritsch, R; Romanin, C.
Gating and permeation of Orai channels.
Front Biosci (Landmark Ed). 2012; 17(24): 1304-1322.
Doi: 10.2741/3988
Web of Science
PubMed
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FullText_MUG
- Co-authors Med Uni Graz
- Schindl Rainer
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- Abstract:
- Ca2+ release-activated Ca2+ channels mediate a sustained Ca2+ influx following depletion of endoplasmic reticulum stores. This signalling cascade that triggers T-cell activation or mast cell degranulation involves STIM1, the Ca2+ sensor in the endoplasmic reticulum, and the Ca2+ selective Orai channel in the plasma membrane. This review describes the molecular mechanism (s) governing the STIM1/Orai signalling machinery. Moreover, we provide an overview on additional proteins modulating or interacting with the STIM1/Orai1 system. A structure-function relationship highlights regions within STIM1/Orai proteins contributing to activation, permeation and inactivation of CRAC currents.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Ion Channel Gating -
- Signal Transduction -
- Find related publications in this database (Keywords)
- STIM1
- Orai
- CRAC
- Activation
- Permeation
- Gating
- Inactivation
- Review