Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Parakaw, T; Suknuntha, K; Vivithanaporn, P; Schlagenhauf, A; Topanurak, S; Fucharoen, S; Pattanapanyasat, K; Schechter, A; Sibmooh, N; Srihirun, S.
Platelet inhibition and increased phosphorylated vasodilator-stimulated phosphoprotein following sodium nitrite inhalation.
Nitric Oxide. 2017; 66(6):10-16
Doi: 10.1016/j.niox.2017.02.008
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Schlagenhauf Axel
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- Abstract:
- In the presence of red blood cells (RBCs), nitrite inhibits platelets through its conversion to nitric oxide (NO) by the reductase activity of partially deoxygenated hemoglobin. Inhaled sodium nitrite is being investigated as a therapy for pulmonary hypertension. Here, we measured platelet aggregation, P-selectin expression, platelet-leukocyte aggregates and phosphorylated vasodilator-stimulated phosphoprotein (P-VASPSer239) following sodium nitrite inhalation in healthy subjects. In vitro incubation of nitrite with deoxygenated whole blood showed an increase in P-VASPSer239, which was inhibited by ODQ, a soluble guanylyl cyclase (sGC) inhibitor. Immediately and 60 min after nitrite inhalation, P-VASPSer239 increased in platelets. Platelet aggregation, P-selectin expression, platelet-monocyte and platelet-lymphocyte aggregates decreased after inhalation. In conclusion, sodium nitrite administered to healthy subjects by inhalation can inhibit platelet activation and increase P-VASPSer239 in platelets. Platelet inhibition by nitrite administration may be useful in disorders associated with platelet hyperactivity. Copyright © 2017 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Inhalation -
- Adult -
- Blood Platelets - drug effects
- Blood Platelets - metabolism
- Cell Adhesion Molecules - blood
- Cell Adhesion Molecules - chemistry
- Cell Adhesion Molecules - metabolism
- Female -
- Humans -
- Male -
- Microfilament Proteins - blood
- Microfilament Proteins - chemistry
- Microfilament Proteins - metabolism
- Nitric Oxide - metabolism
- Nitrites - blood
- Oxygen - metabolism
- Phosphoproteins - blood
- Phosphoproteins - chemistry
- Phosphoproteins - metabolism
- Phosphorylation -
- Platelet Activation - drug effects
- Sodium Nitrite - administration & dosage
- Sodium Nitrite - pharmacology
- Find related publications in this database (Keywords)
- Inhaled nitrite
- Platelets
- Vasodilator-stimulated phosphoprotein
- Nitric oxide
- Deoxygenation